AMOXICILLIN

Amoxil, Ibiamox

Reviewed by Brenda Hughes (pharmacist), Dr Lesley Voss (SCH I.D), Eamon Duffy (pharmacist/I.D)
August 2016
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Amoxicillin Administration

Description

Prescription

Administration

Slow IV Injection12,14,15

 

Amoxicillin 250mg

Amoxicillin 500mg

Powder Space

0.2ml 0.4ml

Water to be added

2.3ml 4.6ml
  100mg in 1.0ml 100mg in 1.0ml
  1. Shake vigorously. Use immediately after reconstitution.
  2. Filter before administration through a 0.2 micron Pall filter.
  3. Administer by slow IV injection over 3-5 minutes.
  4. Compatible with sodium chloride 0.9%, dextrose 5% (the preferred diluent is sodium chloride 0.9% as the solution is more stable) . However must be used immediately after reconstitution, especially if dextrose 5 % is used as the diluent.
  5. Do NOT mix with other drugs, IV solutions, blood or blood products.
  6. Flush line with sodium chloride 0.9% before and after infusion of amoxicillin
  7. Keep patient well hydrated to avoid the possibility of amoxicillin crystalluria.

Nursing Considerations

  1. Observe for signs of adverse effects.
  2. Observe IV site carefully during administration.
  3. Observe for signs of renal,or haematological dysfunction during prolonged therapy.

Storage

References

1

Prober CG, Stevenson DK, Benitz E. The use of antibiotics in neonates weighing less than 1200 grams. Pediatr Infect Dis J 1990; 9:111
2 Kaplan JM, McCracken GH, Horton LJ, et al: Pharmacologic studies in neonates given large dosages of ampicillin. J Pediatr 1974; 84:571.
3 Axline SG, Yaffe SJ, Simon HJ: Clinical pharmacology of antimicrobials in premature infants: II. Ampicillin, methicillin, oxacillin, neomycin, and colistin. Pediatrics 1967; 39:97.
4 Young TE, Magnum OB, Neofax. A manual of drugs used in neonatal care. 10th Edition 1997, p8-9.
5 The Northern Neonatal Network Neonatal Formulary. BMJ Books 2nd Edition 1998, p47.
6 Mehta DK (ed).  British National Formulary (BNF 39; March 2000).  London: British Medical Association and the Royal Pharmaceutical Society, 2000.
7 Reynolds JEF (ed).  Martindale: The Extra Pharmacopoeia (31st edition).  Royal Pharmaceutical Society, 1996: London
8 Charles BG, Preechagoon Y, Lee TC, Steer PA, Flenady V, Debuse N.  Population pharmacokinetics of intravenous amoxycillin in very low birth weight infants.  J Pharmac Sciences 1997; 86(11):1288-92.
9 Huisman-de Boer J, Van den Anken J, Vogel M, Goessens W, Schoemaker RC, Groot R.  Amoxicillin pharmacokinetics in preterm infants with gestational ages of less than 32 weeks.  Antimicrobial Agents and Chemotherapy 1995; 39:431-4.
10 Starship Clinical Guidelines/Meningitis/June 2016
11 New Zealand Formulary (NZF). NZF v[50]. [2016]. Available from: www.nzf.org.nz (Accessed [August], [2016])
12 Ibiamox (amoxycillin) [New Zealand data sheet]. Douglas Pharmaceuticals Ltd [updated 6/10/2011]. Available from URL: http://www.medsafe.govt.nz
13 Sutherland J, Ponen S, Wilson S (eds). [Amoxicillin] Notes on Injectable Drugs, 7th edition. New Zealand Hospital Pharmacists’ Association Inc, Wellington, 2015Australian Injectable Drugs Handbook (6th ed.). Victoria, Australia: The Society of Hospital Pharmacists of Australia, 2014.
14 McEvoy G (ed.). Handbook on Injectable Drugs (18th ed.). Bethesda: American Society of Health-System Pharmacists, Inc,2015.