Management of Ceftazadime Administration

Description

• White to pale yellow powder for reconstitution. 500 mg/vial, 1 gm/vial.
• Reconstituted solution is clear and effervescent. May range from light yellow to amber. Potency is not affected by these colour variations.
• No preservative.

• Stat dose is charted on stat page of prescription chart in mg/dose.
• Maintenance doses are charted on the prescription chart in mg/dose.

Administration

Slow IV Infusion

1. Reconstitute with water to 100 mg/ml. Water should be added in two stages.

   	Ceftazadime 500mg	Ceftazadime 1gram
   Powder Space	0.5ml	1.0ml
   Water to be added	4.5ml	9.0ml
   	500mg in 5.0ml	1gram in 10.0ml

2. Shake vigorously. Allow 1-2 minutes for carbon dioxide to be released before drawing up dose. Filter prior to administration via a 0.2 micron Pall filter. Small bubbles in solution may be disregarded.
3. Does not require further dilution.
4. Administer by slow IV infusion over 30 minutes using a syringe pump.
5. Compatible with D5W, D10W and NS. Do NOT mix with other drugs, IV solutions, blood, or blood products. (Incompatible with aminoglycosides, sodium bicarbonate and vancomycin).
6. Flush line with NS before and after infusion of ceftazadime.

Nursing Considerations

1. Observe site closely for extravasation during administration.
2. Observe for signs of adverse effects.
3. Observe for signs of renal, hepatic or haematological dysfunction during prolonged therapy.
4. Monitor for signs of super-infection.

Storage

• Store at room temperature <25° C until reconstituted.
• Protect from light.
• Is not suitable for storage.

References