|Reviewed by Dorothy Cooper|
|<29||0 to 28||12|
|30 to 36||0 to 14||12|
|37 to 44||0 to 7||12|
Bacteriocidal third generation cephalosporin antibiotic which is resistant to most beta-lactamases and is active against a wide range of gram positive and gram negative bacteria. Inactive against Streptococcus faecalis, many staphylococci and many strains of Bacteroides fragilis. A useful anti-pseudomonal agent, especially in combination with aminoglycosides or penicillin. Active by inhibiting cell wall mucopeptide synthesis.
Poor oral absorption. Widely distributed at varying concentrations in human body tissues and fluids. Very little passes into the CSF unless the meninges are inflamed. Low binding (10%) to human plasma protein. Ceftazadime is not metabolised in the body. Excreted via the kidney. Reduction in serum concentrations can be achieved by peritoneal dialysis/haemodialysis. Serum half life in neonates is 4-10 hours.