Dopamine DBL, Dopamin
NICU and Dept. of Pharmacy
Management of Dopamine Administration
- Clear, colourless solution 40 mg/ml in 5 ml ampoules.
- pH 2.5-4.5 (contains 1% sodium metabisulfite)
Charted on fluid chart giving:
- rate in ml/hour
- dose in micrograms/kg/minute
Also charted on drug chart under
continuous infusions giving:
- amount of drug to be added
- base fluid type and volume
- rate in mL/hour and dose in micrograms/kg/minute
Should be administered via a
central line (UVC, Longline, or Surgical CVL).
If no central access available, use a cannula in a large vein.
- Administered by a nurse with Neonatal IV Drug Certification.
- Discoloration of solution (yellow, brown, pink, purple) indicates
decomposition and should be discarded.
- Dilute 30 mg/kg (0.75 ml/kg) dopamine to make 50ml with NS or D5W - 1
ml/hour = 10 micrograms/kg/minute.
- Compatible with sodium chloride 0.9%, glucose 5% and glucose 10%
- Compatible at Y injection site with dobutamine, morphine, heparin, PGE1.
- Incompatible with acyclovir, indomethacin, insulin, frusemide,, sodium
bicarbonate and other alkaline solutions including phenytoin. No information
available on IVN, therefore avoid co-infusion if possible.
- Do NOT mix with any other drug, blood, or blood products. Do
NOT flush line.
- Administer via a syringe pump.
- Change fluid and tubing every 48 hours or earlier if solution is
- Monitor for adverse reactions.
- Observe closely for IV filtration;
discontinue immediately and notify doctor/NS-ANP. Avoid extravasation of drug as
may cause necrosis and tissue sloughing.
- Assess colour and temperature of extremities.
- Continuous blood pressure
monitoring. If a disproportionate rise in diastolic pressure (decreased pulse
pressure) notify doctor/NS-ANP immediately.
- Continuous cardiorespiratory monitoring.
- Document vital signs hourly and PRN.
- Monitor urinary output.
- At room temperature <30°C.
Protect from light.
- Diluted solution stable for 48
hours at room temperature.
Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric
injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System
Martin, J, Managing editor.
BNF for children 2010-2011. London:
BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd; 2010.
Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell
Young TE, Mangum B, editors. Neofax: A manual of drugs used in neonatal
care. 18th ed. Raleigh, North Carolina, USA: Acorn Publishing; 2005.
Trissel LA. Handbook on Injectable Drugs.
American Society of Health-System Pharmacists (ASHP) 16th Edition.