DOPAMINE HYDROCHLORIDE

Dopamine DBL, Dopamin

Reviewed by NICU and Dept. of Pharmacy
November 2011
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

 

Management of  Dopamine Administration

Description

Prescription

Charted on fluid chart giving:

Also charted on drug chart under continuous infusions giving:

Administration

Continuous Infusion

Should be administered via a central line (UVC, Longline, or Surgical CVL).
If no central access available, use a cannula in a large vein.

  1. Administered by a nurse with Neonatal IV Drug Certification.
  2. Discoloration of solution (yellow, brown, pink, purple) indicates decomposition and should be discarded.
  3. Dilute 30 mg/kg (0.75 ml/kg) dopamine to make 50ml with NS or D5W - 1 ml/hour = 10 micrograms/kg/minute.
  4. Compatible with sodium chloride 0.9%, glucose 5% and glucose 10%
  5. Compatible at Y injection site with dobutamine, morphine, heparin, PGE1.
  6. Incompatible with acyclovir, indomethacin, insulin, frusemide,, sodium bicarbonate and other alkaline solutions including phenytoin. No information available on IVN, therefore avoid co-infusion if possible.
  7. Do NOT mix with any other drug, blood, or blood products. Do NOT flush line.
  8. Administer via a syringe pump.
  9. Change fluid and tubing every 48 hours or earlier if solution is discoloured.

Nursing Considerations

  1. Monitor for adverse reactions.
  2. Observe closely for IV filtration; discontinue immediately and notify doctor/NS-ANP. Avoid extravasation of drug as may cause necrosis and tissue sloughing.
  3. Assess colour and temperature of extremities.
  4. Continuous blood pressure monitoring. If a disproportionate rise in diastolic pressure (decreased pulse pressure) notify doctor/NS-ANP immediately.
  5. Continuous cardiorespiratory monitoring.
  6. Document vital signs hourly and PRN.
  7. Monitor urinary output.

Storage

References

1 Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System Pharmacists; 2007.
2 Martin, J, Managing editor. BNF for children 2010-2011. London: BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd; 2010.
3 Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell Publishing; 2007
4 Young TE, Mangum B, editors. Neofax: A manual of drugs used in neonatal care. 18th ed. Raleigh, North Carolina, USA: Acorn Publishing; 2005.
5 Trissel LA. Handbook on Injectable Drugs. American Society of Health-System Pharmacists (ASHP) 16th Edition.