|Reviewed by Dr
Ferrous sulphate is available in a solution labelled 150mg/5ml, which provides 6mg of
elemental iron per ml.
Dose and Administration
- 0.5ml/kg/day (3mg/kg/day of elemental iron) in two divided doses.
- All infants with a birthweight<2500g or a gestation at birth <37 weeks
- Infants outside these
criteria should be discussed with a specialist first.
- Commence at 2 weeks of age or on discharge, whichever occurs earliest.
- 1ml/kg/day (6mg/kg/day of elemental iron) in two divided doses.
- Prophylaxis for iron deficiency anaemia in low birthweight infants with reduced body iron stores.
- Treatment of documented iron deficiency anaemia.
Contraindications and Precautions
- Peptic ulcer.
- Haemolytic anaemias.
Iron is an integral part of
haemoglobin. Although the major portion of iron in the body is in the form of
haemoglobin, a small amount is also stored in tissues as haemosiderin and
ferritin, and in blood it is bound to transferrin, a carrier protein.
The intestine is the primary site
for both absorption and excretion of iron. Food and antacid decrease the
absorption of iron.
Iron is rigidly conserved in the
body. Most of the iron released from breakdown of haemoglobin in the liver is
Possible Adverse Effects
- Gastrointestinal disturbance:
- Nausea, vomiting, constipation.
- Dark stools (green or black).
- Erosion of gastric mucosa.
- In preterm infants may cause increased red cell haemolysis and haemolytic anaemia
because of low serum values of vitamin E.
- Acute toxicity: gastrointestinal disturbances worsened, CNS disorders (lethargy),
pallor, cyanosis, shock.
- Monitor Hb, PCV, reticulocytes.
- Vitamin C may increase iron absorption.