Management of Flucloxacillin Administration

Description

• White powder for reconstitution 500 mg/vial.
• Reconstituted solution is a pale straw colour. pH 5-7.

• Stat dose to be charted on stat page of prescription chart in mg/dose.
• Maintenance doses are charted on the prescription chart in mg/dose.

Administration

Slow IV Injection

1. Make up immediately prior to use.
2. Reconstitute with water to 250 mg/ml.

3. Shake vigorously.
4. Dilute immediately prior to use to 50 mg/ml by adding to NS using our usual dilution method.
5. Filter prior to administration through a Pall 0.22 micron filter or a Pall 0.22 micron filter. Administer by slow IV injection over 3-5 minutes.
6. Compatible with NS, D5W. Incompatible with aminoglycosides.
7. Do NOT mix with other drugs, IV solutions, blood or blood products.
8. Flush line with NS before and after infusion of flucloxacillin.

Nursing Considerations

1. Assess IV site carefully before and during injection of flucloxacillin for extravasation.
2. Observe for signs of adverse effects.
3. Observe for signs of renal, hepatic or haematological dysfunction during prolonged therapy.
4. Observe for signs of super-infection.

Storage

• Store at room temperature until reconstitution.
• Should be used within 30 minutes following reconstitution.
• Is not suitable for storage.

References