FUROSEMIDE

Furosemide, Frusemide DBL, Lasix

Reviewed by Dr Carl Kuschel, Brenda Hughes, and Karen Anderson-Hawke
June 2005
Change of generic name to Furosemide November 2007
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Furosemide Administration

Description

IV Preparation

Oral Preparation

Prescription

Continuous Infusion

Charted on fluid chart giving:

Also charted on drug chart under "continuous infusion" giving:

Administration

Slow IV Injection

  1. Dilution is not required.
  2. Administer by slow IV injection over 5 minutes. Filter prior to administration through a 0.2 micron Pall in-line filter.
  3. Do NOT mix with other drugs, IV solution, blood or blood products.
  4. Always flush with sodium chloride 0.9% after IV drug administration to prevent precipitation when mixing with drugs of low pH.

Continuous IV Infusion

  1. Compatible with 0.9% sodium chloride (preferred diluent) and 5% dextrose.
  2. Administer via a syringe pump. Change fluid and tubing every 24 hours. Do not use discoloured solutions.
  3. Not compatible with dobutamine, dopamine, gentamicin, midazolam, and morphine. 8 Other drug compatibilities should be checked.

Oral

  1. Preferably give one hour prior to feeds.  The presence of food may decrease bioavailability.  1

Nursing Considerations

  1. Assess for signs of adverse effects.
  2. Assess IV site carefully for signs of extravasation.
  3. Record urine output accurately, especially for infants on continuous infusions.
  4. Measure serum electrolytes, blood glucose, SBR.

Storage

IV preparation. Oral Solution.
Store at room temperature <25°C. Store in refrigerator.  Do not freeze.
Protect from light. Discard 3 weeks from opening.

References

1 Micromede x Healthcare Series.  Vol 122.
2 Mirochnick MH, Miceli JJ, Kramer PA, Chapron DJ, Raye JR. Furosemide pharmacokinetics in very low birthweight infants. J Pediatr 1988; 112:653-7.
3 Wilson NJ, Adderley RJ, McEnniery JA. Supraventricular tachycardia associated with continuous furosemide infusion. Can J Anaesthesia, 38(4 PT1):p502-5.
4 Northern Neonatal Network.  Neonatal formulary 3.  London: BMJ Books 2000.
5 Singh NC, Kissoon N, al Mofada S, Bennett M, Bohn DJ. Comparison of continuous versus intermittent furosemide administration in post-operative pediatric cardiac patients. Critical Care Medicine 1992; 20(1):p17-21.
6 Sweetman S (ed.).  Martindale: the extra pharmacopoeia, 2005.
7 Frusid data sheet.  Douglas Pharmaceuticals, Auckland, 1999.
8 Trissel LA. Handbook on Injectable Drugs. 12th edition. Bethesda (MD): American Society of Health System Pharmacists; 2003.