|Reviewed by Dorothy Cooper|
Dose revised to nanograms April 2003
- 50-500 nanograms/kg/min (0.05-0.5 mcg/kg/min) by continuous IV infusion.
|Isoprenaline (mg) in 50ml IV solution =||
3 x weight
(kg) x dose (mcg/kg/min)
IV rate (ml/hr)
Isoprenaline hydrochloride is a synthetic sympathomimetic amine that is structurally related to adrenaline. The drug is a B1 and B2 adrenergic agonist with almost no activity on a receptors. Increases cardiac output by increasing heart rate, contractility and venous return. Lowers peripheral vascular resistance. Relaxes most smooth muscles, especially bronchial and gastrointestinal. Decreases pulmonary artery pressure and pulmonary artery resistance in experimental animals. Stimulates insulin secretion. Metabolised in the liver and other tissues by catechol-o-methyl transferase. Marked chronotropic and arrhythmogenic effects. May cause myocardial ischaemia or necrosis.