|Reviewed by Dr Carl Kuschel, Brenda Hughes, and Robyn Wilkinson|
Amendment to dilution instructions February 2007 - Diane Hogan, CNE
Management of Morphine Sulphate Administration
- Charted on the stat page of prescription chart in micrograms/dose.
- Maintenance doses are charted on the prescription chart in micrograms/dose.
- Bolus doses of a continuous infusion should be charted on the stat page as
Bolus of morphine infusion with the strength, volume to be administered, and dose in micrograms
e.g. For a 1kg baby, prescribe "Bolus morphine infusion (25 micrograms/kg in 0.5ml) - dose 2ml (100 micrograms) IV"
Charted on the fluid chart giving:
- dose in micrograms/kg/hour
- rate in ml/hour.
Also charted on drug chart under continuous infusions giving:
- amount of drug to be added
- base fluid, type and volume
Slow IV Injection
Administered by nursing staff except the first dose in the non-ventilated postoperative baby.
|Bhat R, Gopal C, Gulati A, Aldana 0, Velamati R, Bhargava H. Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life. J Pediatr 1990; 117:477-81.|
|Bhat R, Abu-Harb M, Gopal C, Gulati A. Morphine metabolism in acutely ill preterm infants. J Pediatr 1992; 120:795-9.|
|Lynn AM, Slattery JT. Morphine pharmacokinetics in early infancy. Anesthesiologyr 1987: 66:136-9.|
|Koren 0, Butt W, Chinyanga H, Soldin S, Tan Y, Pape K. Postoperative morphine infusion in newborn infants: Assessment of deposition characteristics and safety. J Pediatr 1985; 107:963-7.|
|Hartley R, Levene MI. Opioid pharmacology in the Newborn In: Baillieres Clinical Paediatrics Vol 3, No 3, p 467-493, August 1995.|