PARACETAMOL

Panadol, Pamol

Reviewed by Dr Salim Aftimos, Brenda Hughes, Robyn Wilkinson, Sanya Mirkov
July 2000
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Paracetamol Administration

Description

Prescription

Administration

  1. Oral: Shake well before use. Do NOT dilute.

Observation and Documentation

  1. Monitor for signs of adverse effects
  2. Assess for toxicity: CNS stimulation, excitement
  3. Evaluate baby's need for, and response to medication.

Storage

Selected References

1 Levy G, Khanna NN, Soda DM, et al. Pharmacokinetics of acetaminophen in the human neonate; Formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Paediatrics 1975; 55:818.
2 Miller RP, Roberts RJ, Fischer LJ. Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther 1975; 19:284.
3 Knight J, Saunders R (eds). New Ethicals Compendium. Auckland, Adis Press 1992, p328-329.
4 Anderson BJ, Woollard GA, Holford NHG. A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children. Br J Clin Pharmacol. In press. 2000 .
5 Medicines for Children. Royal College of Paediatrics and Child Health. London: RCPCH Publications Limited, 1999.