Dose and Administration
- Curosurf 2.5ml/kg (200mg/kg phospholipid) via endotracheal tube, 4
administered by a doctor/NS-ANP.
- Inject as a single bolus directly into ETT. 5
- Administer rapidly as quickly as the baby tolerates it.
- Baby is supine and flat throughout.
- Subsequent doses should not be given no less than 6 hours, and up to
12hours after the preceding dose. The second and subsequent doses should be
1.25 ml/kg (100 mg/kg phospholipid).
The usual criteria for administering a second dose are:
- Need for positive pressure ventilation, and
- FiO2 >0.30
- Some infants may require more than 2 doses. This should only be on the instruction of a specialist.
Respiratory Distress Syndrome in preterm infants.
- Other conditions with presumed surfactant deficiency (discuss with
Contraindications and Precautions
- Use in infants weighing <700g is not established.
- Efficacy of poractant in the treatment of Meconium Aspiration Syndrome and
Group B Streptococcal Pneumonia has not been proven.
A natural porcine surfactant derived from minced pig lungs. Surfactant
is extracted using chloroform or methanol and then purified using liquid-gel
chromatography. It is then sterilised via a high pressure filter system
and then finally suspended in an isotonic saline solution to a final
concentration of 80mg/ml phospholipids. It also contains surfactant
apoproteins SP-B and SP-C.
Poractant increases the degree of mechanical stability of the alveoli and
reduces surface tension. A surfactant monolayer is formed at the
air-liquid interface, allowing all areas of lung to expand and contract.
Poractant is absorbed extremely rapidly. Infants typically show a rapid
improvement in oxygenation within minutes of the dose.
Possible Adverse Effects
- Instability during administration.
- Possible ETT blockage.
- Rapid changes in lung compliance and blood gases.
- Slight increased risk of pulmonary haemorrhage.
- Increased risk of nosocomial infections.
- Should be used after consultation with specialist.
- Staff need to be careful with vial size selection, as inappropriate vial
selection may result in high wastage and therefore increased cost.
- Monitor O2 saturation, ECG continuously and blood gases and
adjust ventilator/oxygen appropriately.
- Suction prior to administration if necessary but avoid suctioning if possible for 6 hours following doses.
- Jewish and Muslim parents: use in these populations should be
discussed with parents. Poractant has been used extensively in Israel and
as it is not per se ingested, its use is considered acceptable.
Parents should be informed that alternative non-porcine preparations are not
Note: The table indicating which sized vial to open for any given baby has
been deleted as staff do not use the table to decide which sized vial to open
and it is not always evident which baby will require a second dose.