Lactobacillus acidophilus & Bifidobacterium bifidum & Bifidobacterium
Jane Alsweiler and Elizabeth Oliphant
Parent Information Sheet (PDF)
Prophylactic probiotics have been shown to reduce the incidence of
mortality1 and sepsis2
in preterm babies.
- ORAL administration
- Labinic drops come in a 5 mL bottle.
- When the bottle is first opened remove the dropper and write the date on
- Gently shake the bottle from side to side.
- Use a sterile oral syringe to draw up the dose.
- Mix with EBM or formula (any volume of ≥ 1 mL), and administer
immediately via NG tube. Labinic can either be added to milk feeds, or given
directly into the mouth if babies are breast feeding.
- Labinic drops will be charted on the prescription chart by a doctor or
nurse specialist-advanced neonatal practitioner.
- Labinic drops are given until 36 weeks’ gestational age or discharge,
whichever is first.
- ≤ 32 weeks’ gestational age OR ≤1500 g birth weight
- AND tolerating 24 hours of oral feeds (EBM or NIF, > 1 mL q4hourly)
Contraindications and Precautions
- Nil by mouth
- Use with caution in acutely unwell babies or babies with short bowel
Possible Adverse Effects
- Sepsis with the probiotic organisms has been reported.3
- Labinic drops can be kept at room temperature (<25ºC). As the NICU room
temperature is maintained at 25 ºC keep the Labinic drops in the fridge.
- Labinic drops come with a dropper in the top of the bottle, which is not
reliable. This should be removed, and an oral syringe used to extract each
- Parents should give verbal consent for their baby to be given probiotics.
A parent information sheet is available
- Microbiological surveillance of Labinic drops is performed by Eurofin
laboratories 3 monthly as recommended by the practice guideline.4
- Contains 1.5 billion bacteria per dose.
AlFaleh K, Anabrees J. Probiotics for
prevention of necrotizing enterocolitis in preterm infants. Cochrane
Database Syst Rev. 2014;Issue 4. Art. No.: CD005496. DOI:
Rao S, Athalye-Jape G, Deshpande G, Simmer
K, Patole S. Probiotic supplementation and late-onset sepsis in preterm
infants: a meta-analysis. Pediatrics. 2016;137(3):e20153684.
Land MH, Rouster-Stevens K, Woods CR,
Cannon ML, Cnota J, Shetty AK. Lactobacillus sepsis associated with
probiotic therapy. Pediatrics. 2005;115(1):178-81.
Deshpande G, Rao S, Keil A, Patole S.
Evidence-based guidelines for use of probiotics in preterm neonates. BMC