of Immunoglobulin (IVIG)
|Reviewed at Clinical Practice
IVIG 3g in 50ml (6% solution)
l0ml aliquots available for neonatal use.
Contains antibodies to normal
range of infections in New Zealand.
Prepared by cold ethanol
fractionation and is free of HIV, and Hepatitis B and C virus transmission
pH 4 for IV use only.
Adults sometime react to IVIG
with fall in blood pressure. Baby should be watched carefully particularly
at the start of the infusion.
Most patients have no side
effects at all.
Low pH should be considered
in sick babies with acid/base problems. Undiluted it is hyperosmolar.
Should be given over 1 hour or longer.
If high osmolarity or low
pH are a potential problem may be given diluted with equal volumes of
saline, ½ normal saline or 5% dextrose.
- Treatment of Immune Thrombocytopenia
- IVIG 2g/kg in divided doses over 4 days, i.e, 0.5g/kg/day = 8.3ml/kg
given over a 3 hour period each day.
- Treatment of Isoimmune Haemolytic Jaundice
- IVIG 0.5g/kg over 2-4 hours, can be repeated after 12 hours.
After consultation with ARBC
Medical Officer, write Blood Products request form with
patient's name, number, date of birth, birthweight and present weight.
et at, Vox Sang 51: suppl 2, 22-29 (1986).
et at: Peds, 109:3; 505-508 (1986)
Pediatr Infect Dis J, 1993, 12:549-59
Neonatal Jaundice. NICE Clinical Guideline
2008. National Institute for Health and Clinical Excellence, 2010.
Management of Hyperbilirubinaemia in the
Newborn Infant 35 or More Weeks of gestation. AAP Guideline. Paediatrics
For further details see the Big
Blue Blood Bank Book.