Reviewed by Dr Pat Clarkson, Robyn Wilkinson, Brenda Hughes, Lejla Brkic
January 1999
Reviewed By Dr Jon Skinner, October 1999
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Adenosine Administration




  1. Administered by doctor or NS-ANP with doctor in attendance.

  2. Dilute immediately prior to use to 1mg / ml by adding to sodium chloride 0.9% using our usual dilution method.

  3. Filter prior to administration through a 0.22 micron filter

  4. Administer by direct IV injection over 1 to 2 seconds.

  5. Follow instantaneously with a rapid flush of sodium chloride 0.9%

  6. Compatible with sodium chloride 0.9%. Adenosine 1mg/mL compatible with glucose 5% 10

Nursing Considerations

  1. Continuous ECG printout during and immediately after administration IS ESSENTIAL. File record in patient notes
  2. Where practical record blood pressure prior to first dose
  3. Continuous cardio-respiratory monitoring. Observe closely for arrhythmia.
  4. Monitor and assess patient response to therapy.
  5. Observe for signs of adverse effects and arrhythmias
  6. Ensure resuscitation equipment available.



1 Adenosine Drug evaluation monograph. 1974 - 1993 Micromedex Inc. Vol 78, Exp 11/30/93.
2 Sanofi Winthrop Pty Ltd. When seconds count, count on Adenocor (Product Information) 1995. Oxford Clinical Communications Australia Pty Ltd.
3 Beral CI. Higher adenosine dosage required for supraventricular tachycardia in infants treated with theophylline. Clin Pediatrics 1993: 167-168.
4 Paul T, Pfammatter JP. Adenosine. An effective and safe antiarrhythmic drug in pediatrics. Paed. Cardiology 1997: 18; 118-126.
5 Stockley I. Drug Interactions 4th ed. The Pharmaceutical Press; 1996: London
6 Hansten P, Horn J. Drug Interactions Analysis and Management. Applied Therapeutics Inc.; July 1998: Vancouver.
7 Crosson J, Etheridge SP, Milstein S, Hesslein PS, Dunnigan A. Therapeutic and diagnostic utility of Adenosine during tachycardia evaluation in children. Am J Cardiol 1994; 74:155-160
8 Sherwood M, Lau K, Sholler G. Adenosine in the management of supraventricular tachycardia in children J Paediatr Child Health 1998;34:53-56
9 Ralston M, Knilans T, Hannon D, Daniels S. Use of adenosine for diagnosis and treatment of tachyarrhythmias in pediatric patients J Pediatr 1994; 124: 139-143
10 Ketkar V, Kolling W, et al. Stability of undiluted and diluted adenosine at three temperatures in syringes and bags. Am J Health- Syst Pharm 1998; 55: 466-70