Reviewed by Brenda Hughes
September 2009
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of  Amikacin Administration

Description 1,2,6



Slow IV Infusion

  1. No further dilution required ( 5mg/ml).
  2. For infants <1000 grams administer as close to the intravascular catheter (LL, UVC, IV) as possible to avoid the need for large NaCl flushes.  Note that the prepared syringes are pre-filtered so no added Pall filter is required.
  3. Administer by slow IV infusion over 30 minutes using a syringe pump.
  4. Incompatible with Heparin.
  5. Do not mix with other drugs, IV solutions, blood or blood products.
  6. Flush line with 0.9% NaCl before and after infusion of Amikacin.
  7. Compatible with 0.9% NaCl or 5% Dextrose.

Nursing Considerations

  1. Trough and peak levels (if requested) - 1 hour after the infusion commences, 30 minutes after the infusion ceases.
  2. Observe site for extravasation during administration.
  3. Observe for signs of renal, hepatic and haematological dysfunction during prolonged therapy.



1 Amikacin Data Sheet. Auckland: Baxter Healthcare Ltd., 2000.
2 Amikin® Data Sheet. Australia: Bristol-Myers Squibb,2001.
3 Stockley I. Drug Interactions 5th ed. London :The Pharmaceutical Press; 2000.
4 Northern Neonatal Network. Neonatal Formulary 3. London: BMJ Books, 2000.
5 Sweetman S (ed.) Martindale: The Extra Pharmacopoeia. (33rd ed). London : Royal Pharmaceutical Society; 2002.
6 Trissel LA. Handbook of Injectable Drugs (10th edition). American Society of Hospital Pharmacists; 1998: Bethesda
7 Treluyer JM, Merle Y, Tonnelier S, Rey E, Pons G. Nonparametric population pharmacokinetic analysis of amikacin in neonates, infants, and children. Antimicrob Agents Chemother 2002; 46:1381-7.
8 Young TE, Mangum B. Neofax. 15th edition. Acorn publishing (Raleigh) 2002. P4-5.
9 Kotze A, Bartel PR, Sommers DK. Once versus twice daily amikacin in neonates: prospective study on toxicity. J Paediatr Child Health 1999; 35:283-6.
10 Shore K, Morris A.  Amikacin as a replacement aminoglycoside for netilmicin for coagulase-negative staphylococcal sepsis in neonates (letter).  NZMJ 2001; 115(1163):216
11 Prober CsG, Yeager AS, Arvin AM. The effect of chronological age on the serum concentrations of amikacin in sick and preterm infants. J Pediatr 1981; 98:636.
12 Myers MG, Roberts RJ, Mirhij NH. Effects of gestational age, birthweight and hypoxaemia of pharmacokinetics of amikacin in serum of infants. Antimicrob Agents Chemother 1977; 11:1027.
13 Nursing 97 Drug Handbook 1997 Springhouse p67-8.