|Reviewed at Senior Paediatric Meeting|
Any variation in dosing, to be discussed with Cardiologist/Neonatal Specialist
Amiloride hydrochloride is a weak diuretic with potassium sparing properties.
It also exhibits natriuretic and hypotensive effects. It is chemically unrelated
to other known diuretics. Amiloride acts directly on the distal renal tubule of
the nephron to inhibit sodium-potassium ion exchange. Unlike spironolactone,
amiloride does not competitively inhibit aldosterone and its diuretic activity
is independent of aldosterone.
It is completely absorbed from the gastrointestinal tract. Simultaneous administration of food decreases gastrointestinal absorption from about 50% to about 30%. The drug has large extravascular distribution. It is not significantly bound to human plasma protein. Amiloride is not metabolised and is eliminated by the kidney (50%) and in the faeces (about 40%).
Onset of action about 2 hours and its diuretic action reaches a peak in 6 - 10 hours and may persist for about 24 hours.
|1||Paediatric Pharmacopoeia, Royal Children’s Hospital, Melbourne 2002|
|2||British National Formulary 2012-13. BMJ Group, the Royal Pharmaceutical Society of Great Britain, and RCPCH Publications Ltd 2012|