AMPHOTERICIN B Deoxycholate
(conventional amphotericin)

Fungizone®

Amphotericin B X-Gen®

Reviewed by Brenda Hughes(Pharmacy),
Dr Lesley Voss & Dr Elizabeth Wilson (ID Starship)
June 2015
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of  Amphotericin Administration

Description

Prescription

Administration

Slow IV Infusion

Nursing Considerations

Nursing Considerations

  1. Ensure patient is adequately hydrated before and during therapy.
  2. Obtain baseline FBC, serum electrolytes, renal and liver function tests. Repeat these measurements regularly during therapy
  3. Monitor and document vital signs including blood pressure and fluid balance.
  4. Assess IV site carefully before and during infusion of amphotericin.
  5. Observe for signs of adverse effects.

Storage

References

1 Bradley JS, Nelson JD (eds.). Nelson’s Pediatric Antimicrobial Therapy (20th ed.). 2014.
2 Brayfield A (ed). Martindale: The Complete Drug Reference (38th ed.). London: Pharmaceutical Press, 2014.
3 Paediatric Injectable Guidelines (4th ed.). Melbourne: The Royal Children’s Hospital, 2011.
4 McEvoy G (ed). Handbook on Injectable Drugs (18th ed.). Bethesda: American Society of Health-System Pharmacists , Inc., 2015.
5 X-Gen Amphotericin B data sheet. New York: X-Gen Pharmaceuticals, 2010.