Reviewed by Dr Carl Kuschel, Dorothy Cooper
August 1998
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Atropine Administration




Slow IV Injection

  1. Is administered by the doctor / NS-ANP. In an emergency situation the nurse may administer under the direct supervision of the doctor present.
  2. Further dilution not necessary.
  3. Administer IV by slow injection over 1 minute.
  4. Filter prior to administration through a Pall 0.2 micron filter.
  5. Compatible with D5W and NS.
  6. Do NOT mix with other drugs, IV solutions, blood and blood products.
  7. Flush line with NS before and after administration of atropine.

IM Injection

  1. Further dilution not necessary.

Administration of Intratracheal Atropine

  1. Administered by Doctor/NS-ANP or Nurse with neonatal IV drug certification.
  2. Instil into endotracheal tube followed immediately by 1ml NS.

Nursing Considerations

  1. Observe IV site for signs of extravasation.
  2. Assess for signs of adverse effects.
  3. Continuous cardiorespiratory monitoring.
  4. Document vital signs hourly and PRN.
  5. Monitor fluid balance.
  6. Ensure good oral care.
  7. Monitor temperature closely for hyperthermia.
  8. Observe for gastric distension.



1 Roberts RJ. Drug therapy in infants: Pharmacologic principles and clinical experience. Philadelphia, WB Saunders, 1984 p284-7.
2 Adams RG, Verma P, Jackson M, Miller RL. Plasma pharmacokinetics of intravenously administered atropine in normal human subjects. J Clin Pharmacol 1982; 22:477.
3 Kattwinkel J, Fanaroff AA, Klaus M. Bradycardia in preterm infants: Indications and hazards of atropine therapy. Pediatrics 1976; 58:494.
4 Young TE, Mangum OB, Neofax. A manual of drugs used in neonatal care. 11th Edition 1998, p102-3.