AMOXICILLIN AND
CLAVULANIC ACID

Augmentin®, M-Amoxiclav, Amoxicillin clavulanate, Synermox®, Co-Amoxiclav, Curam

Reviewed by Brenda Hughes (Pharmacist), Natasha Pool (Pharmacist ID) & Dr Elizabeth Wilson (ID SCH)

 July 2017

Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Augmentin Administration

Description

Intravenous

Oral Syrup

Prescription

Intravenous and Oral

Administration1,3,5

Slow IV Injection

  1. Reconstitute with water for injection to 60 mg/ml immediately prior to use.
 

M-amoxiclav 600mg

M-amoxiclav 1.2 gram

Powder Space

0.5ml 0.9ml

Water to be added

9.5ml 19.1ml

Final Concentration

60mg in 1 ml 60mg in 1 ml
  1. Shake vigorously and administer, through a PALL 0.2 micron filter, the prescribed dose by slow IV injection over 5 minutes.
  2. The reconstituted solution of 60 mg in 1ml must be administered within 20 minutes of preparation.
  3. NOT compatible with glucose 5%, glucose 10%, sodium bicarbonate, intravenous lipid emulsion, blood products, midazolam, and metronidazole.

Oral

  1. Reconstitute powder according to instructions on the bottle label.
  2. Administer each dose with food – to reduce gastrointestinal intolerance.
     

Nursing Considerations

  1. Monitor renal
  2. Maintain adequate hydration

Storage1,2,3

Intravenous:

Oral:

References

1

New Zealand Formulary for Children (NZFc). Amoxicillin + clavulanic acid, NZF v[59]. [2017]. Available from: www.nzfc.org.nz (Accessed [May], [2017])
2 BNF for Children 2016-2017. London: BMJ Group, Pharmaceutical Press and RCPCH Publications Ltd; 2016.
3 Amoxiclav multichem® data sheet. Auckland: Multichem NZ Limited, 2016.
4 Augmentin® data sheet. Auckland: GlaxoSmithKline NZ Limited, 2013.
5 McEvoy G. (ed.) Handbook on Injectable Drugs 18th ed. Bethesda: American Society of Health-System Pharmacists, Inc: 2015.