Crystapen, Pencillin Sodium Biochemie

Reviewed by Clinical Practice Committee and Dr Lesley Voss, Natasha Pool and Elizabeth Oliphant
March 2018
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Management of  Benzylpenicillin Administration




Slow IV Infusion

  1. Reconstitute with water to 100mg/ml immediately prior to use. 6
Powder Displacement For both Crystapen and Biochemie
Powder space 0.4ml
Water to be added 5.6ml
  600mg in 6.0ml
  1. Shake vigorously. Filter before administration through a Pall 0.2 micron filter.
  2. Does not require further dilution.
  3. Administer IV by infusion over at least 5 minutes.
  4. Compatible with D5W and NS.
  5. Do NOT mix with other drugs, IV solutions, blood or blood products.
  6. Flush line with NS before and after infusion of penicillin.

Intramuscular Injection

  1. Reconstitute with water to 300 mg/ml immediately prior to use.
Powder Displacement For both Crystapen and Biochemie
Powder space 0.4ml
Water to be added 1.6ml
  600mg in 2.0ml
  1. Penicillin reconstituted to 300mg/ml is not suitable for IV administration, due to high osmolality.

Nursing Considerations

  1. Observe IV site carefully for extravasation during administration.
  2. Observe for signs of adverse effects.
  3. Observe for hypernatraemia.



1 Prober CG, Stevenson DK, Binitz WE. The use of antibiotics in neonates weighing less than 1200 gm. Pediatr Infec Dis J 1990; 9:111.
2 McCracken GH, Ginsburg C, Chrane DF, et al. Clinical pharmacology of penicillin in newborn infants. J Pediatr 1973; 82:692.
3 The Northern Neonatal Network, Neonatal Formulary BMJ Books, 2nd Edition 1998, p176.
4 Nursing 97 Drug Handbook Springhouse p 98-9.
5 Penicillin G sodium Biochemie product enclosure.
6 Neonatal Pharmacopoeia (2nd ed.). Pharmacy dept. Royal Women's Hospital, Melbourne. 2005