Description

• White powder for reconstitution 600 mg/vial.
• Reconstituted solution is clear, pale, straw coloured.
• pH 6-7.5. Is inactivated in alkaline solutions.

• Stat dose is charted on stat page of prescription chart in mg/dose.
• Maintenance doses are charted on the prescription chart in mg/dose.

Administration

Slow IV Infusion

1. Reconstitute with water to 100mg/ml immediately prior to use. ⁶

Powder Displacement	For both Crystapen and Biochemie
Powder space	0.4ml
Water to be added	5.6ml
	600mg in 6.0ml

2. Shake vigorously. Filter before administration through a Pall 0.2 micron filter.
3. Does not require further dilution.
4. Administer IV by infusion over at least 5 minutes.
5. Compatible with D5W and NS.
6. Do NOT mix with other drugs, IV solutions, blood or blood products.
7. Flush line with NS before and after infusion of penicillin.

Intramuscular Injection

1. Reconstitute with water to 300 mg/ml immediately prior to use.

Powder Displacement	For both Crystapen and Biochemie
Powder space	0.4ml
Water to be added	1.6ml
	600mg in 2.0ml

2. Penicillin reconstituted to 300mg/ml is not suitable for IV administration, due to high osmolality.

Nursing Considerations

1. Observe IV site carefully for extravasation during administration.
2. Observe for signs of adverse effects.
3. Observe for hypernatraemia.

Storage

• At room temperature <25°C until reconstitution.
• Should be used within 1 hour following reconstitution.
• Is not suitable for storage.

References