|Reviewed by Dr Carl Kuschel, Dorothy Cooper|
Semisynthetic second generation cephalosporin antibiotic for oral administration. Usually active against the following organisms: Staphylococci species, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Proteus spp, Klebsiella spp, Haemophilus influenzae (including most beta lactamase producing ampicillin resistant strains), Neisseria gonorrhoeae, and several anaerobic bacteria (excluding Bacteroides fragilis). Note that Pseudomonas spp and most strains of enterococci, enterobacter spp, indole positive proteus and serratia spp are resistant to cefaclor. Action results from inhibition of synthesis of cell wall mucopeptides.
Cefaclor is well absorbed after oral administration, whether taken with food or while fasting. However, when taken with food, the peak concentration is less and occurs later than that observed when the medicine is administered to fasting subjects. Widely distributed throughout body fluids and tissues. Does not penetrate the CSF. Approximately 60-85% of the drug is excreted unchanged in the urine. Elevated serum concentrations may be reduced by haemodialysis.
Chloramphenicol - antagonistic effect do not use together.