DBL Cefotaxime®, Claforan®
|Reviewed by Brenda Hughes & Liz Oliphant (Pharmacy Dept). Dr Lesley Voss & ID Team Starship.|
Meningitis and / or severe sepsis
Postnatal Age Frequency < 7 days q12h 7 - 21 days ≤1200g q 12h >1200g q 8h ≥21 days ≤2000g q 8h >2000g q 6h Full term neonates
Refer to Starship Clinical Guidelines: Meningitis
Renal impairment: cefotaxime has a high renal clearance, therefore reduce dose in moderate to severe renal impairment. This is particularly important for lower birth weight infants, as the pharmacokinetics of cefotaxime are influenced by birth weight.1, 2
Broad spectrum third generation cephalosporin antibiotic. Refer to Reference Viewer for more information.