DBL Cefotaxime®, Claforan®

Reviewed by Brenda Hughes & Liz Oliphant (Pharmacy Dept). Dr Lesley Voss & ID Team Starship.
January 2013
Administration Newborn Drug Protocol Index Newborn Services Home Page


Dose and Administration


Meningitis and / or severe sepsis

Dose: 50mg/kg

Postnatal Age Frequency
< 7 days q12h
7 - 21 days  1200g q 12h
>1200g q 8h
21 days 2000g q 8h
>2000g q 6h
Full term neonates
>28 days
  Refer to Starship Clinical Guidelines: Meningitis



  1. Neonatal meningitis.
  2. Empirical therapy in infants with suspected sepsis who have previously received multiple courses of antibiotics.


  1. History of hypersensitivity to cephalosporins or major allergic response to a penicillin.


Renal impairment: cefotaxime has a high renal clearance, therefore reduce dose in moderate to severe renal impairment. This is particularly important for lower birth weight infants, as the pharmacokinetics of cefotaxime are influenced by birth weight.1, 2

Drug Interactions

Clinical Pharmacology

Broad spectrum third generation cephalosporin antibiotic. Refer to Reference Viewer for more information.

Possible Adverse Effects

Special Considerations