Cefoxitin DBL, Mefoxin

Reviewed by Dr Carl Kuschel, Brenda Hughes
September 1998
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Cefoxitin Administration




Slow IV Injection

  1. Reconstitute with water to 400 mg/ml.
      Cefoxitin DBL 400mg/ml Mefoxin 400mg/ml
    Powder space 0.5ml 0.7ml
    Water to be added: 2.0ml 1.8ml
      1 gram in 2.5ml 1 gram in 2.5ml

Shake vigorously.  Filter prior to administration via a 0.2 micron Pall filter.

  1. Does not require further dilution.
  2. Administer by slow IV injection over 3-5 minutes.
  3. Compatible with NS, D5W, D10W
  4. Do NOT mix with other drugs, IV solutions, blood or blood products.
  5. Flush line with NS before and after injection of cefoxitin.

Nursing Considerations

  1. Assess site carefully for extravasation during injection of cefoxitin.
  2. Observe for signs of adverse effects.
  3. Observe for signs of renal, hepatic or haematological dysfunction during prolonged therapy.
  4. Observe for signs of super-infection.



1 Prober CG, Stevenson DK, Benitz WE. The use of antibiotics in neonates weighing less than 1200 gm. Pediatr Infec Dis J 1990; 9:111.
2 Brogdon RN, Hall RC, Speight TM, Avery GS. Cefoxitin (mefoxin): A new B lactam antibiotic. New Ethicals, Feb 1979:29-35.
3 Feldman WE, Moffitt S. Sparrow N. Clinical and pharmacokinetic evaluation of parenteral cefoxitin in infants and children. Antimicrob Agents Chemother 1980; 17:669-74.
4 Cefoxitin product disclosure DBL. Faulding Ltd, September 1994.
5 Children's Hospital and Regional Medical Center, Seattle, Washington. Formulary of medications 1998-1999, p133-4.