Reviewed by Dorothy Cooper
September 1998
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Ceftazadime Administration




Slow IV Infusion

  1. Reconstitute with water to 100 mg/ml. Water should be added in two stages.
      Ceftazadime 500mg Ceftazadime 1gram

    Powder Space

    0.5ml 1.0ml

    Water to be added

    4.5ml 9.0ml
      500mg in 5.0ml 1gram in 10.0ml
  1. Shake vigorously. Allow 1-2 minutes for carbon dioxide to be released before drawing up dose. Filter prior to administration via a 0.2 micron Pall filter. Small bubbles in solution may be disregarded.
  2. Does not require further dilution.
  3. Administer by slow IV infusion over 30 minutes using a syringe pump.
  4. Compatible with D5W, D10W and NS. Do NOT mix with other drugs, IV solutions, blood, or blood products. (Incompatible with aminoglycosides, sodium bicarbonate and vancomycin).
  5. Flush line with NS before and after infusion of ceftazadime.

Nursing Considerations

  1. Observe site closely for extravasation during administration.
  2. Observe for signs of adverse effects.
  3. Observe for signs of renal, hepatic or haematological dysfunction during prolonged therapy.
  4. Monitor for signs of super-infection.



1 Prober CG, Stevenson DK, Benitz WE. The use of antibiotics in neonates weighing less than 1200 gm. Pediatr Infec Dis J 1990; 9:111.
2 Odio CM, Umana, MA, Saenz A, et al. Comparative efficacy of ceftazadime vers carbenacillin and amikacin for treatment of neonatal septicaemia. Pediatr Infec Dis 1987; 6:371.
3 Low DC, Bissinden JG, Wise R. Ceftazadime in neonatal infections. Arch Dis Child 1985; 60:360.
4 Prescribing information (product disclosure) Glaxo NZ 1990.
5 Royal Children's Hospital, Melbourne. Paediatric Pharmacopoeia 11th Edition 1994, p28.
6 Young TE and Mangum OB, Neofax. A manual of drugs used in neonatal care, 11th Edition 1998, p18-19.
7 Northern Neonatal Network Neonatal Formulary. BMJ Books 2nd Edition 1998, p72.