CEFUROXIME SODIUM

m-Cefuroxime

Reviewed by Kiri Aikman & Clinical Practice Committee
January 2015
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Cefuroxime Administration4,6

Description

Prescription

Administration

Bolus

  1. Dilute to 100 mg/ml with water for injection
 

Cefuroxime
 (Zinacef/Mylan)
750mg

Cefuroxime
 (Zinacef/Mylan)
1.5g

Powder Space

0.5ml 1ml

Water to be added

7ml 14ml
  100mg/ml 100mg/ml
  1. Shake vigorously.
  2. Administer over 3-5 minutes5,6. Filter before administration through a 0.2 micron Pall filter.
  3. Compatible with sodium chloride 0.9%, glucose 5% and glucose 10%
  4. Do NOT mix with other drugs, IV solutions, strongly alkaline solutions, blood or blood products.
  5. Do NOT mix with sodium bicarbonate solution, amikacin or gentamicin. These drugs are incompatible with cefuroxime when mixed together.
  6. Separate administration from aminoglycoside antibiotics by one hour eg. gentamicin, amikacin.

Storage

Store unopened vials at room temperature . Protect from light

References

1

Taketomo CK, Hodding JH, Kraus DM, Editors. Pediatric & Neonatal Dosage Handbook. 19th Edition. Hudson (OH): Lexi-Comp; 2012
2 Woods, DJ (editor), New Zealand Formulary for Children [Internet]. 2013 [updated 2013 Dec 1; cited 2013 Dec 6]. Available from: www.nzformulary.org
3 Northern Neonatal Network. Neonatal Formulary. 6th edition. Oxford: Wiley-Blackwell Publishing; 2011.
4 Phelps SJ, Hagemann TM, Lee KR, Thompson AJ. Pediatric Injectable Drugs, The Teddy Bear Book. 10th Edition. Bethesda: American Society of Health-System Pharmacists; 2013.
5 Auckland District Health Board, Guardrails Administration Guidelines; Paediatrics. Last updated November 2011
6 Cefuroxime data sheet. Auckland: Mylan New Zealand ltd., 2013.