Reviewed by Dorothy Cooper
September 1998
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Chloramphenicol Administration




Slow IV Infusion

  1. Reconstitute with water to 100 mg/ml.
  Chloramphenicol 100 mg/ml
Powder space 1.0ml
Water to be added 11.0ml
  1.2 grams in 12.0 ml
  1. Shake gently. Filter prior to administration through a 5 micron filter.
  2. Does not require further dilution.
  3. Administer infusion over 30 minutes using a syringe pump.
  4. Compatible with NS, D5W, D10W. Incompatible with many other drugs.
  5. Do NOT mix with other drugs, IV solutions, blood or blood products.
  6. Flush line with NS before and after infusion of chloramphenicol.

Nursing Considerations

  1. Monitor IV site for signs of extravasation phlebitis.
  2. Observe for signs of adverse effects.
  3. Observe for signs of renal, hepatic and haematological dysfunction.



1 Roberts RJ. Drug therapy in infants: Pharmacologic principles and clinical experience. Philadelphia, WB Saunders Co, 1984, p70-74.
2 Rajchgot P, Prober CG, Solden S. Initiation of chloramphenicol therapy in the newborn infant. J Pediatr 1982; 101:1018.
3 Glazer JP, Danish.MA, Plotkin SA, Yaffe SJ. Disposition of chloramphenicol in very low birthweight infants. Pediatr 1980; 67:573.
4 Prescribing information (product disclosure) Parke-Davis.
5 Nursing 97 Drug Handbook Springhouse 1997, p171-8.
6 Northern Neonatal Network Neonatal Formulary BMJ Books, 2nd Edition 1998, p76-77.
7 Young TL and Mangum OB Neofax. A manual of drugs used in neonatal care, 11th Edition 1998, p 22-3.