Reviewed by Dorothy Cooper
September 1998
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Chlorpromazine Administration




IM Injection

  1. Wear gloves when preparing. Contact may cause severe contact dermatitis.
  2. Administer undiluted, deep into a quadriceps muscle. If irritation at IM site occurs, dilute with NS 6.
  3. Compatible with NS 5, D5W and D10W.
  4. Do not mix with other medications in syringe 5.
  5. Must not be given subcutaneously as solution is very irritating. Should not be given by direct IV or intermittent infusion because of tissue irritation 3, 5.


  1. Shake the bottle well before use.
  2. Add required volume to milk 6.

Nursing Considerations

  1. Monitor vital signs including BP for hypotension.
  2. Apnoea monitoring whilst on medication.
  3. Observe for signs of adverse effects.
  4. Patients should remain supine for 30 minutes after IM injection, monitor BP (tachycardia may occur with IM injection) 3, 5.



1 Neonatal Drug Withdrawal. Committee on Drugs. American Academy of Pediatrics. Pediatrics. 1983;72(6):895-902.
2 Zelson C, Estrallita R, Wasserman E. Neonatal Narcotic Addition: 10 year observation. Pediatrics. 1971;48(2):178-189.
3 Reynolds JF, (ed). Martindale - The Extra Pharmacopoeia (30th ed). London: The Pharmaceutical Press, 1993.
4 Prasad AB, (ed). BNF British National Formulary (Sept 95). London: The Pharmaceutical Press, 1995.
5 Squire M, (ed). Notes on Injectable Drugs (2nd ed). Wellington: New Zealand Hospital Pharmacists’ Association Inc, 1994.
6 McEvoy GK(ed). AHFS 94 Drug Information. Bethesda: American Society of Hospital Pharmacists, Inc, 1994.
7 Anand KJS, Arnold JH. Opoid Tolerance and Dependence in Infants and Children. Critical Care Medicine. 1994;22(2):334-342.
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9 Nursing 97 Drug Handbook Springhouse p454.