Dose and Administration

1. Instil one drop in each eye as per the ROP guideline.

Indications

Is used in conjunction with phenylephrine hydrochloride to dilate the pupil in preparation for eye examination.

1. All babies at risk of severe ROP.
2. Intraocular surgery pre and post-operatively.

Contraindications and Precautions

1. Known hypersensitivity to cyclopentolate hydrochloride.
2. Congenital glaucoma.
3. Increased intraocular pressure.
4. Caution in infants with CNS injury.

Clinical Pharmacology

Cyclopentolate produces both mydriasis and cycloplegia. As a mydriatic and cycloplegic cyclopentolate shows its maximum effect 30-60 minutes after instillation. Duration 2-4 hours. Recovery of accommodation occurs within 24 hours. Binds to melanin in the pupil; brown eyes may be less responsive to action and require a greater dose. Systemic absorption can occur and may be minimised by depressing the lacrimal sac for 1-2 minutes after instillation.

Possible Adverse Effects

1. Photophobia.
2. CNS: irritability, restlessness, seizures.
3. Dry mucous membranes.
4. Flushing, fever.
5. Tachycardia.
6. Urinary retention.
7. Bradycardia caused by intraocular pressure during instilling of drops.

Special Considerations

1. See the ROP guideline.