DIAZOXIDE

Diazoxide DBL

Reviewed by Dr Mariam Buksh, Karen Anderson-Hawke (NS-ANP), and Helen Lamb (NS-ANP)
November 2007
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Diazoxide Administration

Description

IV Preparation

Oral Preparation

Prescription

Administration

IV Injection

  1. Administered only intravenously. Do NOT administer IM or SC.
  2. Administered by a doctor/NS-ANP, or a nurse with Neonatal IV Drug Certification.
  3. Do NOT further dilute.
  4. Filter prior to administration through a Pall 0.2 micron filter.
  5. Administer by IV injection over 30 seconds.
  6. No compatibility data available.
  7. Do NOT mix with other drugs, IV solutions, blood or blood products.
  8. Use a separate line for diazoxide.

Oral

  1. Follow instructions on bottle label.
  2. Administer with food.

Nursing Considerations

  1. Observe site closely during administration for extravasation. May cause severe inflammatory reaction.
  2. Observe for signs of adverse effects.
  3. Monitor glucose levels carefully.
  4. Monitor blood pressure (preferably continuously).
  5. Continuous cardiorespiratory monitoring. Observe for arrhythmias.
  6. Monitor fluid balance carefully.
  7. Weigh daily.
  8. Nurse flat during infusion and for 1 hour after infusion.

Storage

IV Preparation

Oral Preparation

References

1 Alexander, S, Anazodo, A and Hussain, K. Interactions of diazoxide with frusemide, spironolactone, and acetylsalicylic acid in a patient with hyperinsulism of infancy and Fallot tetralogy. Eur J Pediatr. 162: 806-807.
2 Aynsley-Green A, Hussain K, Hall J, Saudubray JM, Nihoul-Fekete C, De Lonlay-Debeney P, Brunelle F, Otonkoski T, Thornton P and Lindley KJ. Practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed 2000; 82: F98-F107
3 De Lonlay P, Touati G, Robert Jaen-Jacques and Saudubray J-M. Persistent hyperinsulinaemic hypoglycaemia. Semin Neonatol 2002; 7: 95-100
4 Diazoxide: AHFS Detalied Monogrpah. Medscape.
http://www.medscape.com/druginfo/monograph?cid=med&drugid=10322&drugname=Diazoxide+IV&monotype=monograph. Accessed on 30/07/2007.
5 McGowan JE. Neonatal Hypoglycemia. Neoreviews. July 1999; e6-e15.
6 Lindley KJ, Dunne MJ. Contemporary strategies in the diagnosis and management of neonatal hyperinsulinaemic hypoglycaemia. Early Human Development. 2005; 81: 61-72.