• Note:  This is a Section 29 Drug when administered by oral preparation.  This means that a record must be kept of babies to whom it has been administered, and parents should be informed that it is not registered for oral use in NZ.

Management of Diazoxide Administration

Description

• Clear colourless solution 15 mg/ml in 20 ml ampoules.
• pH adjusted to 11.5 by sodium hydroxide.
• For IV use only.

Oral Preparation

• No proprietary product available. Contact Pharmacy for preparation.

• Individual doses are charted on the stat pages of the drug prescription chart in mg/dose.
• Maintenance doses are charted on the prescription chart in mg/dose.

Administration

IV Injection

1. Administered only intravenously. Do NOT administer IM or SC.
2. Administered by a doctor/NS-ANP, or a nurse with Neonatal IV Drug Certification.
3. Do NOT further dilute.
4. Filter prior to administration through a Pall 0.2 micron filter.
5. Administer by IV injection over 30 seconds.
6. No compatibility data available.
7. Do NOT mix with other drugs, IV solutions, blood or blood products.
8. Use a separate line for diazoxide.

1. Follow instructions on bottle label.
2. Administer with food.

Nursing Considerations

1. Observe site closely during administration for extravasation. May cause severe inflammatory reaction.
2. Observe for signs of adverse effects.
3. Monitor glucose levels carefully.
4. Monitor blood pressure (preferably continuously).
5. Continuous cardiorespiratory monitoring. Observe for arrhythmias.
6. Monitor fluid balance carefully.
7. Weigh daily.
8. Nurse flat during infusion and for 1 hour after infusion.

Storage

IV Preparation

• Unopened store in a cool place <25ºC. Do NOT freeze.
• Protect from light, heat and freezing. Darkened solutions have decreased potency. Do NOT use.
• Discard after use.

• Refrigerate. Do not freeze.
• Protect from light.
• Expires in one week.

References