Dobutamine DBL, Dobutrex
NICU and Dept. of Pharmacy
Management of Dobutamine Administration
- Clear, colourless solution 250mg in 20 ml (12.5 mg/ml in 20ml vials). pH
2.5-5.5. Osmolality is 260 – 280 mOsm/Kg in glucose 5%.
- Contains sodium metabisulfite BP 4.4mg/20ml.
Charted on fluid chart giving:
- rate in ml/hour
- dose in micrograms/kg/minute
Also charted on drug chart under continuous
- amount of drug to be added
- base fluid, type and volume
- infusion rate and dose in micrograms/kg/minute
Should be administered via a central line
(UVC, Longline, or Surgical CVL).
If no central access available, use a cannula in a large vein.
- Administered by a Nurse with neonatal IV drug certification.
- Solution can discolour (pink) but may still be used.
- Dilute 30 mg/kg (2.4 ml/kg) dobutamine to make 50ml with NS or D5W. Mix well.
1 ml/hour = 10 micrograms/kg/minute.
Solution strength should not exceed 5 mg/ml.
- Compatible with NS, D5W and D10W. Also
compatible at Y injection site with dopamine, morphine, insulin and IVN.
- Incompatible with sodium bicarbonate and any strongly alkaline solution.
- Do NOT mix with any other drug, blood or blood products. Do NOT flush line.
- Administer via a syringe pump.
- Change fluid and tubing every 48 hours.
- Observe IV site closely and avoid
extravasation. Dobutamine can cause inflammatory response and tissue ischaemia.
- Monitor for adverse reactions
- Continuous blood pressure monitoring
- Continuous cardiorespiratory monitoring
- Document vital signs hourly and PRN
- Monitor fluid balance
- At room temperature <25° C. Protect from light.
- Diluted solution stable for 48 hours at room temperature.
Data sheet 2008
Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell
Martin, J, Managing editor.
BNF for children 2010-2011. London:
BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd; 2010.
Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric
injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System