Dopamine DBL, Dopamin

Reviewed by NICU and Dept. of Pharmacy
November 2011
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Management of  Dopamine Administration



Charted on fluid chart giving:

Also charted on drug chart under continuous infusions giving:


Continuous Infusion

Should be administered via a central line (UVC, Longline, or Surgical CVL).
If no central access available, use a cannula in a large vein.

  1. Administered by a nurse with Neonatal IV Drug Certification.
  2. Discoloration of solution (yellow, brown, pink, purple) indicates decomposition and should be discarded.
  3. Dilute 30 mg/kg (0.75 ml/kg) dopamine to make 50ml with NS or D5W - 1 ml/hour = 10 micrograms/kg/minute.
  4. Compatible with sodium chloride 0.9%, glucose 5% and glucose 10%
  5. Compatible at Y injection site with dobutamine, morphine, heparin, PGE1.
  6. Incompatible with acyclovir, indomethacin, insulin, frusemide,, sodium bicarbonate and other alkaline solutions including phenytoin. No information available on IVN, therefore avoid co-infusion if possible.
  7. Do NOT mix with any other drug, blood, or blood products. Do NOT flush line.
  8. Administer via a syringe pump.
  9. Change fluid and tubing every 48 hours or earlier if solution is discoloured.

Nursing Considerations

  1. Monitor for adverse reactions.
  2. Observe closely for IV filtration; discontinue immediately and notify doctor/NS-ANP. Avoid extravasation of drug as may cause necrosis and tissue sloughing.
  3. Assess colour and temperature of extremities.
  4. Continuous blood pressure monitoring. If a disproportionate rise in diastolic pressure (decreased pulse pressure) notify doctor/NS-ANP immediately.
  5. Continuous cardiorespiratory monitoring.
  6. Document vital signs hourly and PRN.
  7. Monitor urinary output.



1 Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System Pharmacists; 2007.
2 Martin, J, Managing editor. BNF for children 2010-2011. London: BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd; 2010.
3 Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell Publishing; 2007
4 Young TE, Mangum B, editors. Neofax: A manual of drugs used in neonatal care. 18th ed. Raleigh, North Carolina, USA: Acorn Publishing; 2005.
5 Trissel LA. Handbook on Injectable Drugs. American Society of Health-System Pharmacists (ASHP) 16th Edition.