Reviewed by NICU and Dept. of Pharmacy
November 2011
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of  Doxapram Administration


This brand is not licensed in N.Z. (2011) and therefore only available under Section 29 of the Medicines Act. Prescription



  1. Compatible with glucose 5%, glucose 10%, sodium chloride 0.9%.
  2. Incompatible with parenteral nutrition, alkaline solutions (e.g. sodium bicarbonate , and frusemide so run separately).
  3. Administer as a continuous infusion via a syringe pump
  4. Change preparation every 24 hours

Nursing Considerations

  1. Babies on doxapram will usually also be receiving CPAP and need meticulous care in its application.
  2. Capillary or arterial blood gases as ordered.
  3. Monitor vital signs (BP, pulse rate, saturations).


Selected References

1 Sweetman S. (Ed.) Martindale: The Extra Pharmacopoeia. (33rd. ed). London : Royal Pharmaceutical Society; 2002. 
2 Dopram® (data sheet online). Wyeth-Ayerst Laboratories (Date of preparation 22 June 1999). Available from  http.//
3 Doxapram, Hutchison TA, Shahan DR (eds): Drugdex ® system. Micromedex ® Inc., Greenwood Village, Colorado. (Edition   expires 12/2003).
4 Medicines for Children. Royal College of Paediatrics and Child Health. London: RCPCH Publications Limited, 1999
5 Martin, J, Managing editor. BNF for children 2010-2011. London: BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd; 2010.
6 Barrington KJ, Finer NN, Torok-Both G, Jamali F, Coutts RT. Dose-response relationship of doxapram in the therapy for the refractory idiopathic apnea of prematurity. Pediatrics. 1987; 80 (1):22-27.
7 Huon C, Rey E, Mussat P, Moriette G. Low-dose doxapram for treatment of apnoea following early weaning in very low birthweight infants: a randomized, double-blind study. Acta Paediatr. 1998; 87:1180-4.
8 Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System Pharmacists; 2007.
9 Trissel LA. Handbook on Injectable Drugs. American Society of Health-System Pharmacists (ASHP) 16th Edition.