Erythrocin IV

Reviewed by NICU and Dept. of Pharmacy
November 2011
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Management of  IV Erythromycin  Administration




Slow IV Infusion3

  1. Reconstitute with Water for Injection to 50 mg/ml. Do NOT use sodium chloride 0.9% or glucose 5% to reconstitute as precipitation may occur at this concentration.
1 gram
Water to be added 20 ml
  1 gram in 20.0 ml
  1. Shake vigorously. For peripheral administration, immediately prior to use further dilute to 5 mg/mL with sodium chloride 0.9%. For central line administration may be diluted to 10 mg/mL.
  2. Administer by slow IV infusion over 60 minutes using a syringe pump.
  3. Incompatible with ceftazidime. Unstable in acidic solutions.
  4. Do NOT mix with any other drugs, IV solutions, blood or blood products. Is incompatible with many substances.
  5. Flush line with sodiuim chloride 0.9% before and after infusion of erythromycin.

Nursing Considerations

  1. Monitor vital signs especially heart rate for arrhythmias
  2. Observe for signs of adverse effects eg. diarrhoea, vomiting, allergic reactions.
  3. Observe IV site closely for extravasation during infusion of drug.
  4. Observe for signs of renal, hepatic and haematological dysfunction during prolonged therapy.
  5. Observe for signs of super infection including fungal infection.



1 Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System Pharmacists; 2007.
2 Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell Publishing; 2007
3 Martin, J, Managing editor. BNF for children 2010-2011. London: BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd; 2010.
4 Trissel LA. Handbook on Injectable Drugs. American Society of Health-System Pharmacists (ASHP) 16th Edition.
5 Young TE, Mangum B, editors. Neofax: A manual of drugs used in neonatal care. 18th ed. Raleigh, North Carolina, USA: Acorn Publishing; 2005.