Floxapen, Flucloxin

Reviewed by Clinical Practice Committee, Dr Lesley Voss and Elizabeth Oliphant
January 2018
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Flucloxacillin Administration






Slow IV Injection

  1. Make up immediately prior to use.
  2. Reconstitute with water to 100 mg/ml.
  Flucloxin 250 mg
Powder space:

0.2 ml

Water to be added:

2.3 ml

Resultant concentration

100 mg /ml

  1. Shake vigorously.
  2. Dilute immediately prior to use to 50 mg/ml by adding to 0.9% sodium chloride.
  3. Filter prior to administration through a Pall 0.22 micron filter. Administer by slow IV injection over 3-5 minutes.
  4. Compatible with 0.9% sodium chloride or 5% dextrose. Incompatible with aminoglycosides.
  5. Do NOT mix with other drugs, IV solutions, blood or blood products.
  6. Flush line with 0.9% sodium chloride before and after administration of flucloxacillin.

Oral Administration

  1. Reconstitute with water. Add 87ml of purified water to dry mixture in the bottle. Shake well.
  2. Shake well before use.
  3. Administer on an empty stomach as far as possible – 30-60 minutes before feeds.

Nursing Considerations

  1. Assess IV site carefully before and during injection of flucloxacillin for extravasation.
  2. Observe for signs of adverse effects.
  3. Observe for signs of renal, hepatic or haematological dysfunction during prolonged therapy.
  4. Observe for signs of super-infection.





1 Edmund Hey (2011) Neonatal Formulary 6th Ed, page 111.
2 Douglas Pharmaceuticals Ltd. Flucloxacillin powder injection data sheet. 18 May 2017. http://www.medsafe.govt.nz/profs/datasheet/f/Flucloxincapsyrinj.pdf (accessed 26 October 2017)
3 AFT Pharmaceuticals Ltd. Flucloxacillin capsules and powder for oral solution data sheet. 3 July 2017. http://www.medsafe.govt.nz/profs/datasheet/f/FlucloxacillinAFTcapssoln.pdf (accessed 26 October 2017)
4 Pullen J. et al. (2006) Population Pharmacokinetics and Dosing of Flucloxacillin in Preterm and Term Neonates, Ther Drug Monit 28:351–358
5 Pacifici GM. et al. (2008) Clinical Pharmacokinetics of Penicillins in the Neonate: a review of the literature, European Journal of Clinical Pharmacology, 65; 191–198
6 Pullen J. et al. (2007) Protein Binding of Flucloxacillin in Neonates, Ther Drug Monit, 29:279–283
7 Herngren L. et al. (1987) Pharmacokinetics of Free and Total Flucloxacillin in Newborn Infants, European Journal of Clinical Pharmacology, 32; 403–409
8 Neonatal Medicines Formulary Consensus Group. Flucloxacillin guideline. 10 August 2017