FLUCONAZOLE

Diflucan

Reviewed by NICU and Dept. of Pharmacy

August 2011

Management of IV Fluconazole Administration

Description

Injection fluconazole 2mg/ml . pH:4 – 8. Osmolality 315 mOsm/L
Oral: dry powder for reconstitution to a solution containing fluconazole 50mg/5ml Oral

Prescription

Charted on the prescription chart in mg/dose

Administration

Intravenous

Administer undiluted, through a PALL 0.2 micron filter, over 60 minutes.
Compatible with glucose 5%, glucose 10%, and sodium chloride 0.9%.
Incompatible with frusemide, calcium gluconate. Do NOT mix with other medications.

Oral

Oral doses can be given with food.

Nursing Considerations

Monitor ECG, renal function, LFTs, FBC..
Monitor for diarrhoea and feeding intolerance
Monitor for other adverse effects eg. rash

Storage

Injection vials: room temperature, below 30°C.
Reconstituted oral solution: between 5-30°C (preferably in fridge). Note expiry date on label.

References

1	Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System Pharmacists; 2007.
2	Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell Publishing; 2007
3	Young TE, Mangum B, editors. Neofax: A manual of drugs used in neonatal care. 18th ed. Raleigh, North Carolina, USA: Acorn Publishing; 2005.