Reviewed by NICU and Dept. of Pharmacy
May 2014
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of  IV Fluconazole   Administration





  1. Administer undiluted, through a PALL 0.2 micron filter, over 60 minutes.
  2. Compatible with glucose 5%, glucose 10%, and sodium chloride 0.9%.
  3. Incompatible with frusemide, calcium gluconate. Do NOT mix with other medications.


  1. Oral doses can be given with food.

Nursing Considerations

  1. Monitor ECG, renal function, LFTs, FBC..
  2. Monitor for diarrhoea and feeding intolerance
  3. Monitor for other adverse effects eg. rash


  1. Injection vials: room temperature, below 30°C.
  2. Reconstituted oral solution: between 5-30°C (preferably in fridge). Note expiry date on label.


1 Phelps SJ, Hak EB, Crill CM, editors. Teddy bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American Society of Heath-System Pharmacists; 2007.
2 Hey, E, editor. Neonatal formulary. 5th ed. Oxford: Blackwell Publishing; 2007
3 Young TE, Mangum B, editors. Neofax: A manual of drugs used in neonatal care. 18th ed. Raleigh, North Carolina, USA: Acorn Publishing; 2005.
4 Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants. Wade KC, Benjamin DK Jr, Kaufman DA, Ward RM, Smith PB, Jayaraman B, Adamson PC, Gastonguay MR, Barrett JS.
Pediatr Infect Dis J. 2009 Aug;28(8):717-23