Reviewed by Dr Lesley Voss, Brenda Hughes, Mandy Hodgson, Ruth Tramschek
January 2000
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Flucytosine Administration






Slow IV Infusion

  1. Further dilution not required.
  2. Filter during administration through 0.22 micron Pall in-line filter or 5 micron filter needle.
  3. Administer by slow IV infusion over 20 - 40 minutes using a syringe pump.
  4. Compatible with glucose 5 % and sodium chloride 0.9%.
  5. Do NOT mix with any drug, IV solutions, blood or blood products.
  6. Flush line with sodium chloride 0.9% before and after infusion of flucytosine.

Nursing Considerations

  1. Assess IV site carefully for signs of extravasation.
  2. Observe for signs of adverse effects.
  3. Monitor fluid balance.
  4. Oral dose: Administer with milk to reduce gastro-intestinal adverse effects.



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