FLUCYTOSINE

Alcobon

Reviewed by Dr Lesley Voss, Brenda Hughes, Mandy Hodgson, Ruth Tramschek
January 2000
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Flucytosine Administration

Description

Intravenous

Oral

Prescription

Administration

Slow IV Infusion

  1. Further dilution not required.
  2. Filter during administration through 0.22 micron Pall in-line filter or 5 micron filter needle.
  3. Administer by slow IV infusion over 20 - 40 minutes using a syringe pump.
  4. Compatible with glucose 5 % and sodium chloride 0.9%.
  5. Do NOT mix with any drug, IV solutions, blood or blood products.
  6. Flush line with sodium chloride 0.9% before and after infusion of flucytosine.

Nursing Considerations

  1. Assess IV site carefully for signs of extravasation.
  2. Observe for signs of adverse effects.
  3. Monitor fluid balance.
  4. Oral dose: Administer with milk to reduce gastro-intestinal adverse effects.

Storage

References

1 Johnson DE, Thompson TR, Green TP, Ferrier IP. Systemic candidiasis in very low birthweight infants (less than 1500 gm). Pediatrics 1984; 73:138.
2 Koldin MH, Medoff G. Antifungal chemotherapy. Pediatr Clin North Am 1983; 30:49-61.
3 Bayley J, Meyers C, Kliegman RM, Jacobs MR, Blumer JL. Pharmacokinetics, outcome of treatment, and toxic effects of amphotericin B and 5-fluorocytosine in neonates. J Pediatr 1990; 116:791-7.
4 Children's Hospital and Regional Medical Center, Seattle, Washington. Formulary of Medications, 4th Edition, 1998-99, p273.
5 Reynolds JEF (Ed) Martindale: The Extra Pharmacopoeia. (31st ed). Royal Pharmaceutical Society; 1996: London
6 Alcobon Data Sheet. Auckland: Pacific Pharmaceuticals Ltd.,1999
7 Stockley I. Drug Interactions 4th ed. The Pharmaceutical Press; 1996: London
8 Loe E. et al. Paediatric Pharmacopoeia, Royal Children’s Hospital Melbourne and Leicester Royal Infirmary Children’s Hospital . WB Saunders Co. Ltd; 1998: London
9 Bhatt D, Reber D, Wirtschafter D et al. Neonatal Drug Formulary 4th ed. Kaiser Permanente; 1997
10 Lab Plus (verbal communication with Medicines Info. Centre). 12/1/00.
11 Medicines For Children. Royal College of Paediatrics and Child Health. RCPCH Publications Ltd 1999:London