Furosemide, Frusemide DBL, Lasix
NICU and Dept. of Pharmacy
Management of Furosemide Administration
- Clear solution 10mg/ml in 2 ml ampoules. Osmolality 287 mOsm/kg, pH 8 –
- Do not use if the solution is a yellow colour.
- Use Lasix ® brand, containing frusemide 10 mg/ ml in 30 ml bottles .
- Stat IV and oral doses are charted on stat page of prescription chart in
- Maintenance doses are charted on prescription chart in mg/dose.
Charted on fluid chart giving:
- rate in ml/hour.
- dose in mg/kg/hour.
Also charted on drug chart under "continuous infusion" giving:
- amount of drug to be added.
- type and volume of base fluid.
- note dose as mg/kg/ml.
Slow IV Injection
- Dilution is not required.
- Administer by slow IV injection
over 5 minutes. Filter prior to administration through a 0.2 micron Pall
- Do NOT mix with other drugs, IV solution, blood or blood products.
- Always flush with sodium chloride
0.9% after IV drug administration to prevent precipitation when mixing with
drugs of low pH.
Continuous IV Infusion
- Compatible with 0.9% sodium chloride (preferred diluent) , glucose 5 %
and glucose 10%
- Administer via a syringe pump. Change fluid and tubing every 24 hours.
Do not use discoloured solutions.
- Incompatible with dobutamine, dopamine, gentamicin and other
aminoglycosides midazolam, milrinone and morphine8. Other drug
compatibilities should be checked with ward pharmacist.
- Preferably give one hour prior to feeds. The presence of food may
decrease bioavailability. 1
- Assess for signs of adverse effects.
- Assess IV site carefully for signs of extravasation.
- Record weight, B.P. and pulse rate. Record urine output accurately,
especially for infants on continuous infusions.
- Measure serum electrolytes, blood glucose, SBR.
|Store at room temperature <25°C.
||Store in refrigerator. Do not freeze.
|Protect from light.
||Discard 3 weeks from opening.
Phelps SJ, Hak EB, Crill CM, editors. Teddy
bear book: Pediatric injectable drugs. 8th ed. Bethesda, MD: American
Society of Heath-System Pharmacists; 2007.
Sweetman S (ed.). Martindale: the extra pharmacopoeia, 2005.
Hey, E, editor. Neonatal formulary. 5th ed.
Oxford: Blackwell Publishing; 2007
Martin, J, Managing editor. BNF for children
2010-2011. London: BMJ Group, Pharmaceutical Press & RCPCH Publications Ltd;
Trissel LA. Handbook on Injectable Drugs. American Society of
Health-System Pharmacists (ASHP) 16th Edition.
Young TE, Mangum B, editors. Neofax: A
manual of drugs used in neonatal care. 18th ed. Raleigh, North Carolina,
USA: Acorn Publishing; 2005.