GENTAMICIN SULPHATE

Gentamicin DBL

Reviewed by Clinical Guidelines Committee
April 2012
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Gentamicin Administration

Description

Prescription

Administration

Slow IV Infusion

  1. Dilution not required unless baby <1000 grams.
  2. Dilute to 2 mg/ml for use in ELBW infants.
  3. Administer by IV infusion via BBraun pump over 20-30 minutes. Filter prior to administration through a Pall (0.2 micron) filter.
  4. Compatible with D5W, D10W, 0.9% NaCl and IVN. Incompatible with Intralipid.
  5. Do NOT mix with other drugs, blood or blood products.
  6. Flush before and after administration of gentamicin with 0.9% NaCl

Observation and Documentation

  1. Observe for signs of adverse effects.
  2. Observe for signs of renal, hepatic and haematological dysfunction during prolonged therapy.

Storage

Selected References

1

Koren T, Leeder S, Harding E. Optimisation of gentamicin therapy in very low birthweight infants. Pediatr Pharmacol 1985; 5:79.

2

Heindmarsh KW, Nation RL, Williams GL, et al. Pharmacokinetics of gentamicin in very low birthweight preterm infants. Eur J Clin Pharmacol 1983; 24:649.