GLUCAGON

Glucagen hypokit

Reviewed by Reviewed by Dorothy Cooper
September 1996
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Glucagon Administration

Description

Prescription

Continuous infusion

Charted on fluid chart giving:

Also charted on drug chart under continuous infusions giving:

Administration

Continuous Infusions

  1. Reconstitute with water provided to 1mg/ml.
  2. Add 1mg glucagon to 23ml D5W, D10W to make 1mg in 24ml. Mix well. Do not use if not clear.
  3. Consider compatible in D5W and D10W, precipitates in chloride and calcium solutions. Consider incompatible with all other substances. Use a separate line for glucagon infusions.
  4. Filter prior to administration through a Pall 0.22 micron filter.
  5. Administer via a syringe pump.
  6. Change fluid and tubing every 24 hours.

Slow IV Injection

  1. Reconstitute with water to 1mg/ml immediately prior to use.
  2. Does not require further dilution. Filter prior to administration.
  3. There is no data available on drug or additive compatibilities. Consider incompatible with all other substances. Precipitates in chloride and calcium solutions.
  4. Administer by slow IV injection over 1 minute.
  5. Flush with D5W before and after administration of glucagon.
  6. Do NOT mix with any drugs, IV solutions, blood and blood products.

IM or SC Injection

  1. Reconstitute with water to 1mg/ml immediately prior to use.

Nursing Considerations

  1. Assess IV site closely for signs of extravasation.
  2. Observe for signs of adverse effects.
  3. Observe clinical condition closely for signs of hypoglycaemia. Monitor blood glucose levels.
  4. Monitor blood pressure regularly.

Storage

References

1 Product disclosure Novo Nordisk Pharmaceuticals Ltd, Denmark, March 1996.
2 Hawdon et al, Arch Dis Child 68; 255, 1993.
3 Pawlak RP, Herfert LAT. Drug administration in the NICU. 2nd Ed 1991; P110-111.
4 Young TE, Mangum OB, Neofax. A Manual of Drugs used in Neonatal Care. 11th Ed 1998; p 190.
5 Heel RC, Stanaway L. New Ethicals Compendium 1988. Adis Press; p 612-613.
6 Northern Neonatal Network Neonatal Formulary BMJ Books 2nd Edition 1998, p117.
7 Smith JL. 1996 Formulary of Drugs, The Hospital for Sick Children, Toronto, 15th Edition, p60.
8 Children's Hospital and Regional Medical Center, Seattle, Washington. Formulary of Medications, 4th Edition, 1998-99, p295.
9 Nursing 97 Drug Handbook Springhouse 1997, p769.
10 Guys, Lewisham and St Thomas Hospital. Pediatric Formulary 3rd Edition 1993, p80.