Reviewed by Dr Carl Kuschel, Ana Kennedy (NS-ANP), and Dr George Chan (Haematology)
May 2005
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of  Heparin Administration



Flushing of UACs, UVCs, and longlines after insertion

Flushing of luered CVLs and longlines

Continuous infusions are charted on fluid chart giving:



  1. Luered central venous catheters that are not in use are flushed every 72 hours with heparinised saline 10 units/ml.
  2. UACs, UVCs, and longlines are primed with 0.9% NaCl prior to insertion, and after completion of the insertion procedure are flushed with 0.5-1.0ml of Heparin 10 units/ml.
  3. Administer by slow IV injection.
  4. Compatible with D5W, D10W, NS and IVN and Intralipid.
  5. Incompatible with aminoglycoside antibiotics, erythromycin, vancomycin, phenytoin, lorazepam, hyaluronidase.

Volumetric Infusion Pump

  1. Heparin is added to IV fluids as per Newborn services policies.

Observation and Documentation

  1. Monitor for signs of bleeding.


Selected References

1 Monagle P. Chan A. Massicotte P. Chalmers E. Michelson AD. Antithrombotic therapy in children: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(3 Suppl):645S-687S. 
2 Manco-Johnson MJ. Diagnosis and management of thromboses in the perinatal period. SemPerinatol 1990; 14:393-402.
3 McDonald MM, Hathaway WE. Anticoagulant therapy by continuous heparinisation in newborn and older infants. J Pediatr 1982; 101:451-7.
4 Andrew M, Schmidt B. Use of heparin in newborn infants. Semin Thromb Hemost 1988; 14:28-32.