Description

• Pale yellow powder for reconstitution 1 mg/vial. Reconstituted solution is clear. For IV use only.

• Is charted on prescription chart in micrograms/dose.

Administration

Slow IV Infusion

1. Reconstitution (no powder displacement).
   • Reconstitute with 2 ml water or 0.9% NaCl to make 1000 micrograms/2ml (=500 micrograms/ml).
   • This will allow extra volume for ease of administration.
2. Do NOT further dilute as indomethacin becomes very unstable.
3. Draw up into 1ml syringe.
4. Administer by slow IV infusion over 30 minutes using a syringe pump. Filter prior to administration through a 5 micron filter.
5. Is compatible with 0.9% NaCl and water only.
6. Do NOT mix with other drugs, IV solutions, blood or blood products.
7. Ensure the dead space in the IV tubing is considered when administering the very small volumes of indomethacin.
8. Flush with 0.9% NaCl before and after administration of indomethacin.

Observation and Documentation

1. Assess for signs of adverse effects.
2. Maintain strict fluid balance. Report urinary output of<1-2 m1/kg/hour to doctor / NS-ANP.
3. Perform urinalysis 8 hourly for blood, specific gravity and protein.
4. Observe for evidence of bleeding.
5. Assess for signs and symptoms of PDA. Auscultate for PDA closure.
6. Monitor blood pressure at least 4 hourly.

Storage

• At room temperature <30° C until reconstitution.
• Protect from light.
• Reconstituted solution not suitable for storage.

References