|Reviewed by Dorothy Cooper
Dose revised to nanograms April 2003
Management of Isoprenaline Administration
- Clear, colourless solution 1:5000 (0.2 mg/ml [200micrograms/ml] in 1 ml ampoules).
- Contains benzyl alcohol.
Charted on fluid chart giving:
- rate in ml/hour
- dose in nanograms/kg/minute
Also charted on drug chart under
continuous infusions giving:
- amount of drug to be added
- base fluid, type and volume
- Dilute prior to administration.
- Filter prior to administration through a 5 micron filter.
- Compatible with D5W, D10W, NS. Is compatible with furosemide and sodium bicarbonate.
- Do NOT mix with other drugs, IV solutions, blood or blood products.
- Discard any discoloured solution.
- Administer via a syringe pump.
- Cover tubing and syringe with tinfoil.
- Stability of diluted isoprenaline
solutions unknown. Change solution and tubing every 24 hours. Consider more
frequent solution change if baby's clinical condition is deteriorating (solution
may be losing potency).
Observation and Documentation
- Assess for signs of adverse effects.
- Continuous cardiorespiratory monitoring.
- Continuous blood pressure monitoring.
- Monitor central venous pressure.
- Document vital signs hourly and PRN.
- Obtain blood gases before and during drug use.
- Monitor both an upper and a lower TcO2, and pulse oximetry.
- Monitor fluid balance.
- Unopened. Store in refrigerator at 2-8°C. Do NOT freeze.
- Discard ampoule after use.
- Continuous infusion. Change solution and tubing every 24 hours.
Cabal LA, Devaskar U, Siassi V, et al. Cardiogenic shock associated with
perinatal asphyxia in preterm infants. J Pediatr 1980; 96:705.
Daoud FS, Reeves JT, Kelly DB. Isoproterenol as a potential pulmonary
vasodilator in primary pulmonary hypertension. Am J Cardiol 1978;