Reviewed by Dorothy Cooper
September 1996
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of  Magnesium Administration



Slow IV infusion

Individual doses are charted on stat page of drug chart giving.

Continuous Infusions

Charted on fluid chart giving:

Also charted on drug chart under continuous infusions giving:


Continuous Infusion

  1. Administered by a nurse with Neonatal IV Drug Certification.
  2. Dilute prior to use to make an 8% concentration in D5W (80 mg/ml).
    1. Draw up 8ml of 49.3% magnesium sulphate
    2. Add to 42ml D5W
    3. 50ml = 4000 mg in 50ml
                = 80 mg in 1ml
  3. Filter prior to administration through a 5 micron filter.
  4. Compatible with NS, D5W.
    Incompatible with calcium and sodium bicarbonate.
  5. Do NOT mix with other drugs, IV solutions, blood or blood products. Use a separate line for administration of magnesium sulphate.
  6. Administer via a syringe pump.
  7. Change fluid and tubing every 24 hours.

Observation and Documentation

  1. Monitor for adverse reactions.
  2. Monitor blood pressure frequently. (Continuously if possible).
  3. Continuous cardiorespiratory monitoring.
  4. Document vital signs hourly and PRN.
  5. Monitor fluid balance.
  6. Observe for and document seizure activity.
  7. Have resuscitation equipment and ventilatory support available.


Selected References

1 Pawlak RP, Herfert LAT. Drug administration in the NICU, 2nd Ed 1991. Neonatal Network p158-159.
2 Abu-Osba YK, Golal O, Manasra K, Rejjal A. Treatment of severe persistent pulmonary hypertension of the newborn with magnesium sulphate. Arch Dis Child 1992 Jan 67 (1 SPECN); 31-35.
3 Yeh TF Ed. Drug therapy in the neonate and small infant. Year book medical publishers Inc, Chicago, p266-273.
4 Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. A reference guide to fetal and neonatal risk. Williams and Wilkins 2nd Ed 1986; p256-257.