|Reviewed by Dorothy Cooper
Management of Magnesium Administration
- Clear, colourless solution 49.3%, (493mg/ml in 5 ml ampoules).
Slow IV infusion
Individual doses are charted on stat page of drug chart giving.
- amount of drug to be added.
- base fluid type and volume.
- time to be infused.
- total amount to be infused.
Charted on fluid chart giving:
- rate in ml/hour
- dose in mg/kg/hour
Also charted on drug chart under continuous infusions giving:
- amount of drug to be added
- base fluid type and volume
- Administered by a nurse with Neonatal IV Drug Certification.
- Dilute prior to use to make an 8% concentration in D5W (80 mg/ml).
- Draw up 8ml of 49.3% magnesium sulphate
- Add to 42ml D5W
- 50ml = 4000 mg in 50ml
= 80 mg in 1ml
- Filter prior to administration through a 5 micron filter.
- Compatible with NS, D5W.
Incompatible with calcium and sodium bicarbonate.
- Do NOT mix with other drugs, IV solutions, blood or blood products. Use a separate line for administration
of magnesium sulphate.
- Administer via a syringe pump.
- Change fluid and tubing every 24 hours.
Observation and Documentation
- Monitor for adverse reactions.
- Monitor blood pressure frequently. (Continuously if possible).
- Continuous cardiorespiratory monitoring.
- Document vital signs hourly and PRN.
- Monitor fluid balance.
- Observe for and document seizure activity.
- Have resuscitation equipment and ventilatory support available.
- Unopened - store at room temperature <25°C.
- Discard ampoule after opening.
- Do NOT refrigerate.
- Continuous Infusion: Diluted solution stable at room temperature for 24 hours.
Pawlak RP, Herfert LAT. Drug administration in the NICU, 2nd Ed 1991.
Neonatal Network p158-159.
Abu-Osba YK, Golal O, Manasra K, Rejjal A. Treatment of severe
persistent pulmonary hypertension of the newborn with magnesium
sulphate. Arch Dis Child 1992 Jan 67 (1 SPECN); 31-35.
Yeh TF Ed. Drug therapy in the neonate and small infant. Year book
medical publishers Inc, Chicago, p266-273.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. A
reference guide to fetal and neonatal risk. Williams and Wilkins 2nd Ed