MEROPENEM

Merrem

Reviewed by Dr Malcolm Battin, Dr Lesley Voss (Paediatric Infectious Diseases), Brenda Hughes, and Helen Lamb (NSANP)
December 2005
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Meropenem Administration

Description

Prescription

Administration

Infusion

  1. Reconstitute with sterile water for injection immediately prior to use.
 

Meropenem 500mg

Meropenem 1g

Powder

0.44ml

0.9ml

Water for injection to be added

9.6ml

19.1ml

 

500mg in 10ml

1000mg in 20ml

  1. Use this solution within 2 hours of preparation. 4
  2. Administer dose over 15 minutes 4,7 using a PALL 0.2 micron in-line filter. 9
  3. Compatible with sodium chloride 0.9%, glucose 5 % and 10%.
  4. Incompatible with acyclovir, amphotericin, calcium gluconate, metronidazole, intravenous multivitamins, ondansetron. 10
  5. It is preferable not to co-infuse meropenem with parenteral nutrition and Intralipid 20% with vitamins

Nursing Considerations

  1. Observe intravenous site closely for extravasation.
  2. Observe for signs of renal, hepatic, or haematological dysfunction.
  3. Observe for skin rashes.
  4. Measure urine output.

Storage

References

1

Behrman R, Kliegman R, Jenson H,(eds). Nelson Textbook of Pediatrics (17th ed.).  Philadelphia:Saunders, 2004

2

Kemp CA, McDowell J (eds.) Paediatric Pharmacopoeia (13th ed.). Melbourne: Royal Children’s Hospital, 2002

3

Micromedex ® Healthcare Series, 1974 -2005

4

Merrem Data sheet. Auckland: AstraZeneca, 2004

5

Bradley JS. Meropenem: a new, extremely broad spectrum beta-lactam antibiotic for serious  infections in pediatrics. Pediatr Infect Dis J. 1997 Mar;16(3):263-8

6

Blumer J. Pharmacokinetic determinants of carbapenem therapy in neonates and children. Pediatr Infect Dis J. 1996; 15 (8):733-7.

7

van Enk JG, Touw D, Lafeber H. Pharmacokinetics of meropenem in preterm infants. Ther Dr Mon 2001; 23 (3): 198-201

8

Neonatal Formulary 3. BMJ 2000

9

PALL Technical Report. Portsmouth: Pall Life Sciences; 2001

10

Trissel LA. Handbook of Injectable Drugs (10th edition). American Society of Hospital Pharmacists;1998:Bethesda