METRONIDAZOLE

Metronidazole (Baxter)

Reviewed by NICU and Dept. of Pharmacy  
November 2011
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

 

Management of  Metronidazole  Administration

Description

Prescription

Intravenous

Administration

Slow IV Infusion

  1. Further dilution not required.
  2. Filter prior to administration through a Pall 0.22 micron filter.
  3. Administer by slow IV infusion over 30 minutes using a syringe pump (maximum rate of administration 25 mg/minute).
  4. Is compatible with NS, D5W, D10W.
  5. Do NOT mix other drugs, IV solutions, blood or blood products.
  6. Flush line with NS before and after infusion of metronidazole.

Observation and Documentation

  1. Observe for signs of adverse effects.
  2. Observe for signs of renal, hepatic and haematological dysfunction during prolonged therapy.

Storage

Selected References

1 Brogdon RN, Heel RC, Speight TM, Avery GS. Metronidazole in anaerobic infections: a review of its activity. Pharmacokinetics and therapeutic use. Drugs 1978; 16:387-417.
2 Jager Roman E, Doyle PE, Baird-Lambert J, Cvejic M, Buchanan N. Pharmacokinetics and tissue distribution of metronidazole in the newborn infant. J Pediatr 1982; 100:651-654.
3 Amon I, et al. Disposition kinetics of metronidazole in children. Eur J Clin Pharmacol 1983; 24:113
4 Paediatrician/Senior Nurse Meeting, National Women’s Hospital. 20.02.97.