Reviewed by Dr Carl Kuschel and Brenda Hughes
July 2000
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Netilmicin Administration


  1. Single-use syringes of 10 prepared by Biomed. These syringes are prepared as a diluted solution of the proprietary product.
  2. Proprietary ampoules (Schering-Plough) of 150mg/1.5 mL available from Pharmacy. These ampoules contain benzyl alcohol.



Slow IV Infusion

  1. Do not use syringe if seal is broken.
  2. Administer by slow IV infusion over 30 minutes using a syringe pump.
  3. Compatible with sodium chloride 0.9%, glucose 5%, and glucose 10%.
  4. Do NOT mix with other drugs, IV solutions, blood or blood products.

Observation and Documentation

  1. Observe regularly for signs of renal dysfunction.
  2. Observe for signs of other adverse effects.
  3. Ensure patients are well hydrated during therapy 4.


Selected References

1 Ko C-H, Rous J. Comparison between multiple daily dosing and once daily dosing concept of netilmicin in neonates. Audit. South Auckland Health, 2000.
2 Siegal JD, McCracken GH, Thomas M, Threlkeld N. Pharmacokinetic properties of netilmicin in newborn infants. Antimicrob Agents Chemother. 1979; 15:246-53.
3 Granati B, Assael BM, Chung M, et al. Clinical pharmacology of netilmicin in preterm and term infants. J Pediatr 1985; 106:664-9.
4 Kuhn RJ, Nahata MC, Powel DA, Bickers RG. Pharmacokinetics of netilmicin in premature infants. Eur J Clin Pharmacol 1986; 29:685-7.
5 Netromycin Data Sheet. (Medsafe Website). Auckland; Schering-Plough Pty Ltd ,1997