Dose and Administration
- Instil one drop in each eye before eye examination as per the
Is used in conjunction with cyclopentolate hydrochloride
to dilate the pupil in preparation for eye examination.
- All babies at risk of severe ROP.
- Intraocular surgery pre and postoperatively.
Contraindications and Precautions
- Known hypersensitivity to phenylephrine.
- Severe hypertension, ventricular tachycardia.
- Caution in neonates with hyperthyroidism, hypertension, myocardial disease, heart block, bradycardia, bronchopulmonary
Phenylephrine is a sympathomimetic
agent with mainly direct effects on adrenergic receptors. Produces mydriasis
without cycloplegia. It also acts as a conjunctival decongestant. The effect
lasts several hours.
Phenylephrine may lower intraocular pressure temporarily.
Systemic absorption from conjunctival membranes can occur.
Possible Adverse Effect
- Reflex bradycardia, ventricular dysrhythmias, tachycardia.
- Excitability, headache, lacrimation, conjunctival allergy.
- Increase in blood pressure.
- May cause local discomfort.
- Solutions stronger than 2.5% are NOT recommended in the newborn.
- Interactions - beta-blocker: may cause arrhythmias.
- See the ROP guideline.