PROBIOTICS

Lactobacillus acidophilus & Bifidobacterium bifidum & Bifidobacterium infantis

Labinic Drops

Reviewed by Jane Alsweiler and Elizabeth Oliphant
January 2017

Newborn Drug Protocol Index

Newborn Services Home Page

Parent Information Sheet (PDF)


Purpose

Prophylactic probiotics have been shown to reduce the incidence of necrotising enterocolitis,1 mortality1 and sepsis2 in preterm babies.

Dose

Administration

Indications

Contraindications and Precautions

Possible Adverse Effects

Special Considerations

References

1 AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2014;Issue 4. Art. No.: CD005496. DOI: 10.1002/14651858.CD005496.pub4.
2 Rao S, Athalye-Jape G, Deshpande G, Simmer K, Patole S. Probiotic supplementation and late-onset sepsis in preterm infants: a meta-analysis. Pediatrics. 2016;137(3):e20153684.
3 Land MH, Rouster-Stevens K, Woods CR, Cannon ML, Cnota J, Shetty AK. Lactobacillus sepsis associated with probiotic therapy. Pediatrics. 2005;115(1):178-81.
4  Deshpande G, Rao S, Keil A, Patole S. Evidence-based guidelines for use of probiotics in preterm neonates. BMC Medicine. 2011;9:92-105.