Reviewed by Dr Patricia Clarkson, Dr Jon Skinner, Brenda Hughes, Cherry Olsen, Lijla Brkic
November 1999
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page


Management of  Propranolol Administration


IV preparation

Oral preparation



Slow IV Infusion

  1. Compatible with sodium chloride 0.9%, glucose 5%. Do not mix with other IV solutions or drugs.
  2. Dilution not necessary. May be diluted for ease of administration.
  3. Flush line with sodium chloride 0.9% before and after infusion of propranolol.
  4. Filter prior to administration through a 0.22 micron filter.
  5. Administer by slow IV infusion over 10 minutes using a syringe pump.


  1. Preferably given before food. However if there is a necessity to give with food, continue with this method consistently.

Observation and Documentation

  1. Assess for signs of adverse reaction, including hypoglycaemia
  2. Cardiorespiratory monitoring during acute usage. Report and record changes in heart rate and rhythm.
  3. Document vital signs.
  4. Document baby’s response to medication


IV preparation

Selected References

1 Lilley B, Nolan T, Tibbalis J. Paediatric Pharmacopeaia 10th ed. The Royal Children Hospital Melbourne, July 1989 p129.
2 Clark WG, Brater DC, Johnson AR. Goth’s Medical Pharmacology. The CV Mosby Company 12th ed. 1988 p166.
3 Pawlak RP, Herfert LAT. Drug administration in the NICU Neonatal Network 2nd ed. p228-229.
4 Young TE, Mangum OB. Neofax 10th ed. Acorn Publishing; 1997: Raleigh, North Carolina.
5 Yeh TF (ed). Drug therapy in the neonate and small infant. Year Book Medical Publishers Chicago 1985 p112
6 Reynolds JEF Editor Martindale: The Extra Pharmacopoeia. (31st ed). Royal Pharmaceutical Society; 1996: London
7 Stockley I. Drug Interactions 4th ed. The Pharmaceutical Press; 1996: London
8 Heel R (Editor) New Ethicals Compendium (6th ed). Adis International Limited;1997: Auckland