Reviewed by Dorothy Cooper
September 1996
Dose and Pharmacology Newborn Drug Protocol Index Newborn Services Home Page

Management of Spironolactone Administration




  1. Shake well before use as the ingredients will settle at the bottom of the bottle on standing.
  2. Can be administered independant of food.

Observation and Documentation

  1. Assess for signs of adverse effects
  2. Monitor fluid balance
  3. Monitor BP at regular intervals


Selected References

1 Roberts RJ. In: Drug therapy in infants: Pharmacologic principles and clinical experience. Philadelphia, WB Saunders 1984, p243-4.
2 Karim A. Spironolactone; disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev 1978; 8:151.
3 Overdiek HWPM, Hermens WAJJ, Merkus FWHM. New insights into the pharmacokinetics of spironolactone. Clin Pharmacol Ther 1985; 38:469.